In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in regulating cell function. ECM proteins bind to integrins and other cell surface receptors, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis.
Contents
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during development, tumorigenesis, and other disease states. The contributors examine the various ECM proteins and proteoglycans, ECM receptors such as integrins, and the signaling pathways that mediate the effects of the ECM on cells. They also describe ECM functions in specific biological contexts, including angiogenesis, hemostasis, and thrombosis.
Covering not only the biochemistry and cell biology of the ECM but also its roles in development, physiology, and pathology, this volume is an indispensable reference for cell biologists and all those interested in exploring the myriad functions of the ECM.
Contents:
Preface
Overview of the Matrisome—An Inventory of Extracellular Matrix Constituents and Functions
Richard O. Hynes and Alexandra Naba
Basement Membranes: Cell Scaffoldings and Signaling Platforms
Peter D. Yurchenco
The Collagen Family
Silvie Ricard-Blum
Heparan Sulfate Proteoglycans
Stephane Sarrazin, William C. Lamanna, and Jeffrey D. Esko
The Thrombospondins
Josephine C. Adams and Jack Lawler
Tenascins and the Importance of Adhesion Modulation
Ruth Chiquet-Ehrismann and Richard P. Tucker
Fibronectins, Their Fibrillogenesis and In Vivo Functions
Jean E. Schwarzbauer and Douglas W. DeSimone
Integrin Structure, Activation, and Interactions
Iain D. Campbell and Martin J. Humphries
Crosstalk Among TGF? Signaling Pathways, Integrins, and the Extracellular Matrix
John S. Munger and Dean Sheppard
Molecular Architecture and Function of Matrix Adhesions
Benjamin Geiger and Kenneth M. Yamada
Genetic Analyses of Integrin Signaling
Sara A. Wickström, Korana Radovanac, and Reinhard Fässler
Integrins and Extracellular Matrix in Mechanotransduction
Martin Alexander Schwartz
Integrins in Cell Migration
Anna Huttenlocher and Alan Rick Horwitz
Extracellular Matrix Degradation and Remodeling in Development and Disease
Pengfei Lu, Ken Takai, Valerie M. Weaver, and Zena Werb
Extracellular Matrix in Development: Insights from Mechanisms Conserved between Invertebrates and Vertebrates
Nicholas H. Brown
Angiogenesis
Donald R. Senger and George E. Davis
Extracellular Matrix: Functions in the Nervous System
Claudia S. Barros, Santos J. Franco, and Ulrich Müller
Cell–Extracellular Matrix Interactions in Normal and Diseased Skin
Fiona M. Watt and Hironobu Fujiwara
Extracellular Matrix Proteins in Hemostasis and Thrombosis
Wolfgang Bergmeier and Richard O. Hynes
Index