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This book encompasses the exciting developments and challenges in the fast-moving and rapidly expanding research field of single-molecule kinetic analysis of cell signaling that promises to be one of the most significant and exciting areas of biological research for the foreseeable future. Cell signaling is carried out by complicated reaction networks of macromolecules, and single-molecule analyses has already demonstrated its power to unravel complex reaction dynamics in purified systems. To date, most of the published research in the field of single-molecule processes in cells, focus on the dynamic properties (translational movements of the centre of mass) of biological molecules. However, we hope that this book presents as many kinetic analyses of cell signaling as possible. Although single-molecule kinetic analysis of cellular systems is a relatively young field when compared with the analysis of single-molecule movements in cells, this type of analysis is highly important because it directly relates to the molecular functions that control cellular behavior and in the future, single-molecule kinetic analysis will be largely directed towards cellular systems. Thus, we hope that this book will be of interest to all those working in the fields of molecular and cell biology, as well as biophysics and biochemistry.

Table of contents Preface, Yasushi Sako and Masahiro Ueda; List of contributors; 1 Single-molecule kinetic analysis of receptor protein tyrosine kinases, ichio Hiroshima and Yasushi Sako; 2 Single-molecule kinetic analysis of stochastic signal transduction mediated by G-protein coupled chemoattractant receptor, Yukihiro Miyanaga and Masahiro Ueda; 3 Single-molecule analysis of molecular recognition between signaling proteins RAS and RAF, Kayo Hibino and Yasushi Sako; 4 Single-channel structure-function dynamics: The gating of potassium channels, Shigetoshi Oiki; 5 Immobilizing channel molecules in artificial lipid bilayers for simultaneous electrical and optical single channel recordings, Toru Ide, Minako Hirano, and Takehiro Ichikawa; 6 Single-protein dynamics and the regulation of the plasma-membrane Ca2+ pump, Carey K. Johnson, Mangala R. Liyanage, Kenneth D. Osborn, and Asma Zaidi; 7 Single-molecule analysis of cell-virus binding interactions, Terrence M. Dobrowsky and Denis Wirtz; 8 Visualization of the COPII vesicle formation process reconstituted on a microscope, Kazuhito V. Tabata, Ken Sato, Toru Ide, and Hiroyuki Noji; 9 In vivo single-molecule microscopy using the zebrafish model system, Marcel J. M. Schaaf and Thomas S. Schmidt; 10 Analysis of large-amplitude conformational transition dynamics in proteins at the single-molecule level, Haw Yang; 11 Extracting the underlying unique reaction scheme from a single-molecule time series, Chun Biu Li and Tamiki Komatsuzaki; 12 Statistical analysis of lateral diffusion and reaction kinetics of single molecules on the membrane of living cells, Satomi Matsuoka; 13 Noisy signal transduction in cellular systems, Tatsuo Shibata; Index