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Kurzbeschreibung

Nobel laureate Andrew V. Schally provides a foreword to this concise, up-to-date introduction to cancer biology. Ideal for students of molecular or cell biology, and to medical students. Presents both basic and clinical aspects of the topic in a clear and didactic style.

 

Aus dem Inhalt

Introduction

BASIC ASPECTS

Some Introductory Concepts in Tumor Biology: Clonal Evolution and Autonomy Versus Non-autonomy of the Cancer Cells

Cells' Life and Death: Cell Cycle, Senescence and Apoptosis

GENES INVOLVED IN CARCINOGENESIS

Oncogenes

Tumor Supressor Genes

Genomic Instability

A Twist in the (Genetic) Tail: Cancer Epigenetics

Non-autonomous Interactions in Carcinogenesis: The Role of Tumor Stroma

Telomerase and Cellular Immortality

Tumor Angiogenesis

Metastasis

SPECIFIC TOPICS

The Tissue Context as a Determinant of the Tumor-suppressive of Oncogenetic Function of Certain Genes

Cancer Stem Cells

Determination of Therapeutic Efficacy-Pharmacogenomics

Certain Chemicals Induce Cancer: Chemical Carcinogenesis

Hormones and Cancer

Viral Oncogenesis

UNIFYING THE CONCEPTS

Co-operation of Multiple Biological Processes is needed for the Development of Full-fledged Malignancy

Carcinogenesis in Vivo: Animal Models and Basic Approaches to Generate Genetically Modified Animals

Multistage Carcinogenesis in Humans: The Colon Cancer Model

FUTURE PERSPECTIVES

Epilogue