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Quantitative proteomics by mass spectrometry
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Year:
2007
Publisher:
Totowa, NJ, Humana Press
Media group:
Ausleihbestand
Branch | Locations | Status | Reservations | Due date | Barcode | Floor plan | Lending note |
Branch:
Hauptstelle
|
Locations:
NA-30
154
|
Status:
available
|
Reservations:
0
|
Due date:
|
Barcode:
00183636
|
Floor plans:
Floor plan
|
Lending note:
|
About this book
This volume, from the Methods in Molecular Biology series, is a compendium of cutting-edge protocols for quantitative proteomics, and presents the most significant methods used in the field today. The focus on mass spectrometry (MS) is integral, as MS has, and will continue to be, an essential tool in proteomics for studying complex biological systems and human diseases. This volume is an indispensable resource in the search for novel biomarkers.
Several innovative MS quantitative procedures are presented, including a variety of methods for introducing isotopic labels and quantifying post-translational modifications. Some of these methods include growing an organism in isotope-enriched media, performing trypsin proteolysis in the presence of 18O-water, reacting protein samples with isotopically labeled reagents, quantifying relative amount of proteins without the use of any isotopic labels. Attention is also given to state-of-the-art techniques for the characterization of the phosphoproteome and tandem MS for detection of inborn errors of metabolism. Specifically, the procedure for determinations of enzymatic activity could be used for large-scale screening of newborns.
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Statement of Responsibility:
edited by Salvatore Sechi
Year:
2007
Publisher:
Totowa, NJ, Humana Press
Articles:
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Classification:
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NA-30, SP-20
ISBN:
9781588295712
Description:
X, 218 S. : Ill., graph. Darst.
Footnote:
Literaturangaben
Media group:
Ausleihbestand