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NF-B is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli.

 

Written and edited by experts in the field, this volume includes contributions covering the structure of NF-B, its DNA-binding activity and specificity, the role of the inhibitor I-B, and canonical and alternative mechanisms of NF-B activation. The contributors examine the physiological role of NF-B in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-B represents a critical link between inflammation and cancer.

 

Including clinical perspectives on the use of NF-B inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-B was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.

Contents

Preface

Discovering NF-B

David Baltimore

The NF-B Family of Transcription Factors and Its Regulation

Andrea Oeckinghaus and Sankar Ghosh

Specification of DNA Binding Activity of NF-B Proteins

Fengyi Wan and Michael J. Lenardo

A Structural Guide to Proteins of the NF-B Signaling Module

Tom Huxford and Gourisankar Ghosh

The IKK Complex, a Central Regulator of NF-B Activation

Alain Israël

Ubiquitination and Degradation of the Inhibitors of NF-B

Naama Kanarek, Nir London, Ora Schueler-Furman, and Yinon Ben-Neriah

Signaling to NF-B: Regulation by Ubiquitination

Ingrid E. Wertz and Vishva M. Dixit

Selectivity of the NF-B Response

Ranjan Sen and Stephen T. Smale

Control of NF-B-dependent Transcriptional Responses by Chromatin Organization

Gioacchino Natoli

The Regulatory Logic of the NF-B Signaling System

Ellen O’Dea and Alexander Hoffmann

Oncogenic Activation of NF-B

Louis M. Staudt

NF-B as a Critical Link Between Inflammation and Cancer

Michael Karin

The Nuclear Factor NF-B Pathway in Inflammation

Toby Lawrence

Roles of the NK-B Pathway in Lymphocyte Development and Function

Steve Gerondakis and Ulrich Siebenlist

NF-B in the Immune Response of Drosophila

Charles Hetru and Jules A. Hoffmann

NF-B in the Nervous System

Barbara Kaltschmidt and Christian Kaltschmidt

Use of Forward Genetics to Discover Novel Regulators of NF-B

Tao Lu and George R. Stark

Index