About the Book
The newest Legionella volume is a summary of the most current research and investigation in the field. Orginally presented in Chicago at the 6th International Conference on Legionella, the contributions included are written by experts and cover all aspects of this organism.
Legionella: State of the Art 30 Years after Its Recognition is a comprehensive reference source, offering 131 chapters that are divided into four general subject areas for easy use. The four sections cover clinical and diagnostic information, epidemiology, basic microbiology and pathogenesis, and environmental detection and control. All chapters are appropriately referenced and incorporate both extensive reviews and smaller research reports.
Key Features
* Offers an authoritative review of the most current research, covering all aspects of Legionella.
* Presents 131 chapters that are written by leading experts in the field
* Provides an easy-to-use reference source with chapters that are categorized into four general subject areas
Table of Contents
I. Clinical and Diagnostic Aspects of Legionnaires Disease
1. Clinical Features of Legionnaires Disease: a Selective Review, Paul H. Edelstein
2. Treatment of Legionnaires Disease, Jorge Roig and Jordi Rello
3. Diagnostics and Clinical Disease Treatment: Usefulness of Microbiological Diagnostic Methods for Detection of Legionella Infections, Paul Christian Lück, Jürgen Herbert Helbig, Heike von Baum, and Reinhard Marre
4. Hospital and Community-Acquired Legionella Pneumonia: Two Faces of the Same Disease? M. L. Pedro-Botet, L. Mateu, N. Sopena, S. Roure, I. Casas, M. García-Núñez, C. Rey-Joly, and M. Sabrià
5. Risk Factors for Mortality by Legionnaires Disease (1983-2005), N. Sopena, M. L. Pedro-Botet, L. Mateu, S. Roure, I. Casas, M. Esteve, S. Ragull, C. Rey-Joly, and M. Sabrià
6. Trends Observed in Legionnaires Disease in a Hospital in Catalonia, Spain, 1983 2005, I. Casas, M. L. Pedro-Botet, N. Sopena, M. Esteve, L. Mateu, S. Roure, M. García-Núñez, C. Rey-Joly, and M. Sabrià
7. Community-Acquired Pneumonia in Human Immunodefiency Virus Infected Patients: Comparative Study of Streptococcus pneumoniae and Legionella pneumophila Serogroup 1, M. L. Pedro-Botet, N. Sopena, A. García-Cruz, L. Mateu, S. Roure, M. J. Dominguez, I. Sanchez, C. Rey-Joly, and M. Sabrià
8. Nosocomial Legionella Infection in the County of Copenhagen, 2000 2004, Jette M. Bangsborg, Jens Otto Jarløv, and Søren A. Uldum
9. A Question of Time: a Short Review of Data on the Incubation Period between Exposure and Symptom Onset for Legionnaires Disease, Thomas W. Armstrong
10. Severe Legionnaires Disease Successfully Treated with Levofloxacin and Azithromycin, M. L. Pedro-Botet, N. Sopena, C. Tural, A. García-Cruz, L. Mateu, S. Ragull, M. García-Núñez, S. Roure, C. Rey-Joly, and M. Sabrià
11. In Vitro Activities of Various Antibiotics against Legionella pneumophila, A. Seher Birteksöz, Z. Zeybek, and Aysin Çotuk
12. Detection of Legionella pneumophila DNA in Serum Samples from Patients with Legionnaires Disease, Bram M. W. Diederen, Caroline M. A. de Jong, Faïcal Marmouk, Jan A. J. W. Kluytmans, Marcel F. Peeters, and Anneke van der Zee
13. Specific Detection of Legionella in Samples from Patients with Community-Acquired Pneumonia by PCR and a Colorimetric Detection System (Reverse Dot Blot), Jörn Kircher, Alexander Kirchhoff, and Arndt Rolfs
14. Transcription-Mediated Amplification Assay for Detection of Legionella pneumophila in Samples from Patients with Community-Acquired Pneumonia, Marie K. Hudspeth, Kathleen Clark-Dickey, Elizabeth M. Marlowe, Laura G. Schindler, Karen Campbell, and James T. Summersgill
15. Detection of Legionella spp. and Legionella pneumophila-Specific DNA in Respiratory Secretions by PCR-Enzyme-Linked Immunosorbent Assay, Diane S. J. Lindsay, William H. Abraham, Alistair W. Brown, and Giles F. S. Edwards
16. Serological versus Sequence-Based Methods for Legionella Identification, Beatriz Baladrón, Virginia Gil, and Carmen Pelaz
17. Serologic Study of an Outbreak of Legionnaires Disease: Variation of Sensitivity Associated with the Subgroup of Legionella pneumophila sg1 Antigen Used and Evidence of Concurrent Reactivity to Other Atypical Pneumonia Agents, Sverker Bernander, Berndt E. B. Claesson, Eva Hjelm, Nils Svensson, and Martin Hjorth
18. Serotyping of Legionella pneumophila in Epidemiological Investigations: Limitations and Ways Out for Being a Helpful Tool in the Era of Genotyping, Jürgen H. Helbig and Paul Christian Lück
19. Duopath Legionella: a New Immunochromatographic Test for Simultaneous Identification of Legionella pneumophila and Legionella Species, Jürgen H. Helbig, Paul Christian Lück, Britta Kunz, and Andreas Bubert
20. Antigenic Diversity among Legionella Species of a 19-Kilodalton Peptidoglycan-Associated Lipoprotein Determined by Reactivity Patterns to Monoclonal Antibodies, Jin Hee Moon, Jin Ah Yang, Hee Sun Sim, Dae Won Park, Jang Wook Sohn, Hae Kyung Lee, Mi Yeon Park, and Min Ja Kim
21. Evaluation of a New Rapid Immunochromatographic Test using Peptidoglycan-Associated Lipoprotein for Detection of Legionella Antigen in Urine Samples from Adults with Pneumonia, Jang Wook Sohn, Hee Sun Sim, Hye Won Jeong, Dae Won Park, Hee Jin Cheong, Woo Ju Kim, Sun Ae Kim, Young Sik Cho, and Min Ja Kim
22. Rapid Identification of Legionella pneumophila, Legionella anisa, and Legionella taurinensis with Latex Agglutination Reagents, Monique Reyrolle, C. Ratat, J. Freney, M. Leportier, S. Jarraud, and J. Etienne
23. Clinical Presentation, Laboratory Diagnosis, and Treatment of Legionnaires Disease, David R. Murdoch, Thomas J. Marrie, and Paul H. Edelstein
II. Epidemiology and Strain Typing Methods
24. Legionnaires Disease in Europe 1995 2004: a Ten-Year Review, Carol Joseph and Kate D. Ricketts
25. Typing of Legionella pneumophila and Its Role in Elucidating the Epidemiology of Legionnaires Disease, Timothy G. Harrison, Norman K. Fry, Baharak Afshar, William Bellamy, Nita Doshi, and Anthony Underwood
26. Effect of Legionella Testing Patterns on the Apparent Epidemiology of Legionnaires Disease in Australia, Graham Tallis, Agnes Tan, and Norbert Ryan
27. 25 Years of Surveillance for Legionnaires Disease in England and Wales: Why No Improvement? K. D. Ricketts, C. A. Joseph, T. G. Harrison, J. V. Lee, and F. C. Naik
28. Epidemiological Surveillance of Seropositive Legionellosis Cases in Korea During 1999 2002, Hae Kyung Lee, Soo Jin Baek, Yong In Ju, Jae June Bae, Man Suck Park, and Mi-Yeoun Park
29. Prevalence of Legionnaires Disease and Investigation of Risk Factors: Results of an Italian Multicentric Study, Paola Borella, Stefania Boccia, Erica Leoni, Franca Zanetti, Isabella Marchesi, Annalisa Bargellini, Maria Teresa Montagna, Daniela Tat?, Sara Montegrosso, Francesca Pennino, Vincenzo Romano-Spica, Giovanna Stancanelli, and Stefania Scaltriti
30. Seroprevalence of Antibodies to Legionella pneumophila in Northern Italy, R. Cosentina, S. Malandrin, P. Valentini, E. Sfreddo, L. Pirrotta, O. Mercuri, and O. Di Marino
31. A Seroepidemiological Study of Legionella pneumophila Antibodies in Spanish Patients: A 13-Year Retrospective Study, Sebastian Crespi, Albert Torrents, and Miguel A. Castellanos
32. Risk Differences of Legionnaires Disease Associated with Travel in Spain, 1999 to 2004, Ricardo Casas, Rosa Cano, Carmen Martin, and Salvador Mateo
33. Persistence and Genotypic Stability of Legionella in a Potable Water System in a Hotel over a 20-Month Period, M. García-Núñez, J. Ferrer, S. Ragull, E. Junyent, E. Sagrista, A. Soler, I. Sanchez, M. L. Pedro-Botet, N. Sopena, and M. Sabria
34. 10 Years of Legionella Surveillance: Change of Legionella Subtype Preceded Epidemic of Nosocomial Legionnaires Disease, Klaus Weist, Christian Brandt, Christian Lück, Jutta Wagner, Tim Eckmanns, and Henning Rüden
35. Representative Survey of the Scope of Legionnaires Disease and of Diagnostic Methods and Transmission Control Practices in Germany, Tim Eckmanns, Mona Poorbiazar, Henning Rüden, and Lüder Fritz
36. Distribution of Legionella pneumophila Genotypes in Patients and Environmental Sources, Ed P. F. Yzerman, Jacob P. Bruin, Jeroen W. den Boer, Linda P. Verhoef, and Kim W. van der Zwaluw
37. Molecular Comparison of Isolates from a Recurring Outbreak of Legionnaires Disease Spanning 22 Years, Robert F. Benson, Claressa E. Lucas, Ellen W. Brown, Karen D. Cowgill, and Barry S. Fields
38. Sequence-Based Typing of Legionella pneumophila as an Aid in Investigation of Hospital-Acquired Legionnaires Disease, Faiz Fendukly and Sverker Bernander
39. Legionnaires Disease Associated with Death after Near Drowning in Lake Water, Jaana Kusnetsov, Satu Pastila, Silja Mentula, and Diane Lindsay
40. Is Use of Potting Mix Associated with Legionella longbeachae Infection? Results from a Case Control Study in South Australia, Bridget OConnor, Judy Carman, Kerena Eckert, and Graeme Tucker
41. Epidemiological Typing of Legionella pneumophila in the Absence of Isolates, Norman K. Fry, Baharak Afshar, Timothy G. Harrison, and Günther Wewalka
42. Online Identification of Legionella Species by DNA Sequence Analysis: the Macrophage Infectivity Potentiator Gene as an Example, Norman K. Fry, Baharak Afshar, William Bellamy, Anthony Underwood, Timothy Harrison, and Rodney M. Ratcliff
43. Pulsed-Field Gel Electrophoresis Analysis and Sequence-Based Typing of Legionella pneumophila Serogroup 1 Isolates from Japan, Junko Amemura-Maekawa, Fumiaki Kura, Bin Chang, and Haruo Watanabe
44. Development of an Online Tool for European Working Group for Legionella Infections Sequence-Based Typing Including Automatic Quality Assessment and Data Submission, Anthony P. Underwood, William Bellamy, Baharak Afshar, Norman K. Fry, and Timothy G. Harrison
III. Microbiology, Pathogenesis, Immunology, and Genetics
45. Identification of Translocated Substrates of the Legionella pneumophila Dot/Icm System without the use of Eukaryotic Host Cells, Ralph R. Isberg and Matthias Machner
46. Function of Legionella Effectors, Howard A. Shuman, Christopher Pericone, Nadim Shohdy, Karim Suwwan de Felipe, and Margaret Clarke
47. The Legionella pneumophila Dot/Icm Type IV Secretion System, Carr D. Vincent, Kwang Cheol Jeong, Jessica Sexton, Emily Buford, and Joseph P. Vogel
48. Subcellular Localization of the Dot/Icm Type IV Secretion Proteins, Kwang Cheol Jeong, Carr D. Vincent, Emily Buford, and Joseph P. Vogel
49. Defining the Translocation Pathway of the Legionella pneumophila Type IV Secretion System, Carr D. Vincent, Jonathan R. Friedman, and Joseph P. Vogel
50. Loss of a Patatin-Like Phospholipase A Causes Reduced Infectivity of Legionella pneumophila in Amoeba and Macrophage Infection Models, Philipp Aurass, Sangeeta Banerji, and Antje Flieger
51. Identification of a Cytotoxic Legionella pneumophila lpxb Paralogue in a Multicopy Suppressor Screen using Acanthamoeba castellanii as a Selective Host, Urs Albers, Katrin Reus, and Hubert Hilbi
52. Type II Protein Secretion and Twin-Arginine Translocation Promote the Pathogenesis of Legionella pneumophila, Ombeline Rossier and Nicholas P. Cianciotto
53. The Type II Protein Secretion System of Legionella pneumophila Is Important for Growth in Iron-Rich Media and Survival in Tap Water at Low Temperatures, Maria A. Söderberg and Nicholas P. Cianciotto
54. Identification of Putative Substrates of the Legionella pneumophila Tat Secretion Pathway via Two-Dimensional Protein Gel Electrophoresis, E. De Buck, L. Maes, J. Robben, J.-P. Noben, J. Anné, and Elke Lammertyn
55. Identification of Target Proteins of the Lss Secretion System of Legionella pneumophila Corby, Klaus Heuner, Christiane Albert, Sebastian Jacobi, Emmy De Buck, and Elke Lammertyn
56. Legionella pneumophila Mip: New Function for an Old Protein? Sruti DebRoy and Nicholas P. Cianciotto
57. Phospholipases A of Legionella pneumophila: Virulence Factors by Diversity? Antje Flieger
58. Identification and Characterization of Legionella pneumophila Phospholipases A , Sangeeta Banerji, Margret Müeller, Stefan Stevanovic, and Antje Flieger
59. Characterization of GDSL-Hydrolases of the Lung Pathogen Legionella pneumophila, Sangeeta Banerji, Elena Rastew, Björn Hermes, and Antje Flieger
60. Genetic and Structural Examination of the Legiobactin Siderophore, Kimberly A. Allard, Domenic Castignetti, David Crumrine, Prakash Sanjeevaiah, and Nicholas P. Cianciotto
61. Eukaryotic-Like Proteins of Legionella pneumophila as Potential Virulence Factors, Fiona M. Sansom, Hayley J. Newton, and Elizabeth L. Hartland
62. Role of Legionella pneumophila-Specific Genes in Pathogenesis, Hayley J. Newton, Fiona M. Sansom, Elizabeth L. Hartland, and Vicki Bennett-Wood
63. The Hsp60 Chaperonin of Legionella pneumophila: an Intriguing Player in Infection of Host Cells, Audrey Chong, Angela Riveroll, David S. Allan, Elizabeth Garduño, and Raphael A. Garduño
64. Lipopolysaccharide Architecture of Legionella pneumophila Growth in Broth and Host Cells, Jürgen H. Helbig, Esteban Fernandez-Moreira, Enno Jacobs, Paul Christian Lück, and Martin Witt
65. Lag-1 Acetylation of Lipopolysaccharide, Natalie N. Whitfield and Michele S. Swanson
66. Immunochemical Analysis of Legionella pneumophila Outer Membrane Vesicles, Jürgen H. Helbig, Esteban Fernandez-Moreira, P. Christian Lück, Enno Jacobs, and Michele S. Swanson
67. Contribution of Legionellas Surface to the Pregnant Pause Virulence Strategy,Esteban Fernandez-Moreira, Jürgen H. Helbig, and Michele S. Swanson
68. New Insights into Pathogenesis of Legionella pneumophila Infection: from Bedside Findings to Animal Models, Kazuhiro Tateda, Soichiro Kimura, Estu T. Fuse, and Keizo Yamaguchi
69. Induction of Apoptosis during Intracellular Replication of Legionella pneumophila in the Lungs of Mice, M. Santic, M. Molmeret, S. Jones, R. Asare, A. Abu-Zant, M. Doric, and Y. Abu Kwaik
70. The Role of the Phagosomal Transporter (Pht) Family of Proteins in Legionella pneumophila Pathogenesis, John-Demian Sauer and Michele S. Swanson
71. A Role for Phosphoinositide Metabolism in Phagocytosis and Intracellular Replication of Legionella pneumophila, Stefan S. Weber, Curdin Ragaz, Katrin Reus, and Hubert Hilbi
72. Interaction with the Ciliate Tetrahymena sp. May Predispose Legionella pneumophila to Infect Human Cells, Elizabeth Garduño, Gary Faulkner, Marco A. Ortiz-Jimenez, Sharon G. Berk, and Rafael A. Garduño
73. Genetics of Mouse Macrophage Resistance to Legionella pneumophila, Russell E. Vance, Tao Ren, Dario S. Zamboni, Craig R. Roy, William F. Dietrich
74. Role of Birc 1/Naip 5 in Macrophage Function and Susceptibility to Infection with Legionella pneumophila, Anne Fortier and Philippe Gros
75. Locus on Chromosome 13 in Mice Involved in Clearance of Legionella pneumophila from the Lungs, Seiji Kobayashi, Fumiaki Kura, Junko Amemura-Maekawa, Bin Chang, Naoki Yamamoto, and Haruo Watanabe
76. Inflammatory Immune Response to Cytosolic Flagellin Protects Mice from Legionella pneumophila Infection, Michele S. Swanson, Brenda G. Byrne, Natalie W. Whitfield, Etsu T. Fuse, Kazuhiro Tateda, and Ari B. Molofsky
77. A Peptidoglycan-Associated Lipoprotein of Legionella pneumophila Activates Toll-Like Receptor 2 in Murine Macrophages, Mi Jeong Kim, In Kyeong Lee, Jin Ah Yang, Hee Sun Sim, Jang Wook Sohn, and Min Ja Kim
78. Legionella Infection of Bone Marrow Dendritic Cells Induces Modulation by Catechins, James Rogers, Izabella Perkins, Alberto van Olphen, Nich