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Understanding antibiotic chemotherapy at the ecological level is necessary for more permanent advances in development and in the usage of antibiotic agents both old, new, and in the future. This book traces the history of bacteria, from the development of life on earth to the evolution of diversity. It is this diversity that led, almost automatically to the development of pathogens and predators. The relationship of pathogens and host lead to the development of antibiotics and resistance mechanism. Man has extended this process and we now have a situation in which new antibiotics only are effective for a short time. If we are to create long term antibiotics we must design them with this history in mind.

 

This book is intended for students at various levels that will be the microbiology researchers in the time to come. Also microbiology professors, particularly those teaching medical microbiology as well as physicians administering antibiotics daily and researchers in the pharmaceutical industry may find this book useful.

 

Table of contents

 

Preface

 

Legend to the frontispiece

 

Part 1 Origin Of Bacteria

 

1. Origin Of Life Based On Physical Principles

 

2. Preamble To Life

 

3. The First Cell

 

4. Development Of Cell Physiology And Diversity

 

Part 2 Wall Structure

 

5. Covalent Bonds And Tensile Strength Of Biomaterials

 

6. Structure Of The Fabric That Covers A Bacterium

 

7. The Covalently-Linked Sacculus: The Nona-Muropeptide Model

 

8. The Structure Of The Tessera : I.E. The Unit Structure Of The Wall Surface

 

9. Extrusion And Incorporation Into The Wall

 

10. The Role Of Poles In The Growth Strategy Of Bacteria

 

Part 3 Bacterial Morphologies

 

11. Sidewalls Of Gram-Negative Rod-Shaped Bacteria

 

12. Growth Strategies For Gram-Positive Cells

 

13. Wall Growth Strategies For Gram-Negative Cells

 

14. Commas, Vibrios, Spirilla, And Helicobacters; Tapered And Branched Bacteria

 

15. Spirochetes And Spiroplasma And The Special Strategies For CWD (Cell Wall Deficient) Cells

 

16. Coccal Versus Rods-Shaped Cell And The First Bacterium

 

17. Diseases: Old And New, Especially

 

Part 4 Antibiosis

 

18. Lysozymes As Alternatives To ß-Lactams Antibiotics Acting On The Bacterial Wall

 

19. Development Of Wall Antibiotics And Bacterial Counter-Measures

 

20. Antibiotics And Resistance, With An Emphasis On Aminoglycosides

 

21. Future Chemotherapy Aimed At The Bacterial Murein

 

References