Branch	Locations	Status	Reservations	Due date	Barcode	Floor plan	Lending note
Branch: Dauerleihe	Locations: GE-10 58	Status: borrowed	Reservations: 0	Due date: 1/1/2199	Barcode: 00177792	Floor plans: Floor plan	Lending note:

List of Figures ix

Acknowledgments xiii

Chapter 1: Introduction 1

 

PART I: ROBUSTNESS BELOW THE GENE LEVEL 13

 

Chapter 2: The Genetic Alphabet 15

Chapter 3: The Genetic Code 25

Chapter 4: RNA Structure 39

Chapter 5: Proteins and Point Mutations 62

Chapter 6: Proteins and Recombination 78

 

PART II: ROBUSTNESS ABOVE THE GENE LEVEL 91

 

Chapter 7: Regulatory DNA Regions and Their Reorganization in Evolution 93

Chapter 8: Metabolic Pathways 104

Chapter 9: Metabolic Networks 120

Chapter 10: Drosophila Segmentation and Other Gene Regulatory Networks 143

Chapter 11: Phenotypic Traits, Cryptic Variation, and Human Diseases 161

Chapter 12: The Many Ways of Building the Same Body 175

 

PART III: COMMON PRINCIPLES 193

 

Chapter 13: Neutral Spaces 195

Chapter 14: Evolvability and Neutral Mutations 217

Chapter 15: Redundancy of Parts or Distributed Robustness? 228

Chapter 16: Robustness as an Evolved Adaptation to Mutations 247

Chapter 17: Robustness as an Evolved Adaptation to Environmental Change and Noise 270

Chapter 18: Robustness and Fragility: Advantages to Variation and Trade-offs 281

 

PART IV: ROBUSTNESS BEYOND THE ORGANISM 295

 

Chapter 19: Robustness in Natural Systems and Self-Organization 297

Chapter 20: Robustness in Man-made Systems 310

Epilogue: Seven Open Questions for Systems Biology 321

Bibliography 323

Index 359