Branch	Locations	Status	Reservations	Due date	Barcode	Floor plan	Lending note
Branch: Hauptstelle	Locations: ME-20 60	Status: available	Reservations: 0	Due date:	Barcode: 00176079	Floor plans: Floor plan	Lending note:

Contents

Chapter 1 Introduction ................................. . ................ .. .... ... .............. ..... !

Kenneth H. Lundstrom and Mark L. Chiu

Chapter 2 Biology of G Protein-Coupled Receptors ............................................ 3

Kenneth H. Lundstrom

Chapter 3 G Protein-Coupled Receptors as Targets for Drug Discovery.......... 15

Timothy A. Esbenshade

Chapter 4 G Protein-Coupled Receptors as Cardiovascular Drug Targets ........ 37

Mika Scheinin and Amir Snapir

Chapter 5 G Protein-Coupled Receptors and Cancer ........................................53

Martine J. Smit and Remko A. Bakker

Chapter 6 G Protein-Coupled Receptors in Metabolic Disease.......................85

Regina M. Reilly and Christine A. Collins

Chapter 7 G Protein-Coupled Receptors in CNS Drug Discovery................ 109

Rita Raddatz and Deborah S. Hartman

Chapter 8 Recombinant G Protein-Coupled Receptors for Drug

D isco very .......................................................................................... 14 3

Kenneth H. Lundstrom

Chapter 9 High Throughput Screening Assays for G Protein-Coupled

R eceptors .................................. ........................ .................... ........... . 159

Usha Warrior Sujatha Gopalakrishnan, Jurgen Vanhauwe, and David Burns

Chapter 10 Molecular Bioinformatics of Receptor Binding and Activation..... 191

Kevan P Willey, Heike Obermann, and James B. Procter

Chapter 11 Structures and Dynamics of G Protein-Coupled Receptors............ 227

Judith Klein-Seetharaman and Michkle C. Loewen

Chapter 12 Toward Crystallization of G Protein-Coupled Receptors................ 271

Mark L. Chiu and Maria P MacWilliams

Chapter 13 Novel Solid-State NMR Methods for Structural Studies

on G Protein-Coupled Receptors ............... .............. ................. ... 297

Adam Lange and Marc Baldus

Chapter 14 Structural Genomics Initiatives .......................... . .......................... . 315

Kenneth H. Lundstrom

Chapter 15 Molecular Basis of Dimerization of Family A

G Protein-Coupled Receptors ............ ............................................. 325

Graeme Milligan

Chapter 16 Orphan Receptors: Promising Targets for Drug Discovery ............ 337

Yumiko Saito, Zhiwei Wang, and Olivier Civelli

In d ex