Contents
Chapter 1 Introduction ................................. . ................ .. .... ... .............. ..... !
Kenneth H. Lundstrom and Mark L. Chiu
Chapter 2 Biology of G Protein-Coupled Receptors ............................................ 3
Kenneth H. Lundstrom
Chapter 3 G Protein-Coupled Receptors as Targets for Drug Discovery.......... 15
Timothy A. Esbenshade
Chapter 4 G Protein-Coupled Receptors as Cardiovascular Drug Targets ........ 37
Mika Scheinin and Amir Snapir
Chapter 5 G Protein-Coupled Receptors and Cancer ........................................53
Martine J. Smit and Remko A. Bakker
Chapter 6 G Protein-Coupled Receptors in Metabolic Disease.......................85
Regina M. Reilly and Christine A. Collins
Chapter 7 G Protein-Coupled Receptors in CNS Drug Discovery................ 109
Rita Raddatz and Deborah S. Hartman
Chapter 8 Recombinant G Protein-Coupled Receptors for Drug
D isco very .......................................................................................... 14 3
Kenneth H. Lundstrom
Chapter 9 High Throughput Screening Assays for G Protein-Coupled
R eceptors .................................. ........................ .................... ........... . 159
Usha Warrior Sujatha Gopalakrishnan, Jurgen Vanhauwe, and David Burns
Chapter 10 Molecular Bioinformatics of Receptor Binding and Activation..... 191
Kevan P Willey, Heike Obermann, and James B. Procter
Chapter 11 Structures and Dynamics of G Protein-Coupled Receptors............ 227
Judith Klein-Seetharaman and Michkle C. Loewen
Chapter 12 Toward Crystallization of G Protein-Coupled Receptors................ 271
Mark L. Chiu and Maria P MacWilliams
Chapter 13 Novel Solid-State NMR Methods for Structural Studies
on G Protein-Coupled Receptors ............... .............. ................. ... 297
Adam Lange and Marc Baldus
Chapter 14 Structural Genomics Initiatives .......................... . .......................... . 315
Kenneth H. Lundstrom
Chapter 15 Molecular Basis of Dimerization of Family A
G Protein-Coupled Receptors ............ ............................................. 325
Graeme Milligan
Chapter 16 Orphan Receptors: Promising Targets for Drug Discovery ............ 337
Yumiko Saito, Zhiwei Wang, and Olivier Civelli
In d ex
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Verfasserangabe:
edited by Kenneth H. Lundstrom ; Mark L. Chiu
Jahr:
2006
Verlag:
Boca Raton [u.a.], Taylor & Francis
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Systematik:
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ME-20, NA-30
Interessenkreis:
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Sammelwerke
ISBN:
0824725735
Beschreibung:
362 S. : Ill., graph. Darst.
Sprache:
englisch||
Fußnote:
Literaturangaben
Mediengruppe:
Ausleihbestand