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Statistics in clinical vaccine trials

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Author: Search for this author Nauta, Jozef
Year: 2010
Publisher: Berlin, Springer
Media group: Ausleihbestand
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Content

This monograph offers well-founded training and expertise on the statistical analysis of data from clinical vaccine trials, i.e., immunogenicity and vaccine field efficacy studies. The book's scope is practical rather than theoretical. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the statistical methodology. Many real-life examples and SAS codes are presented, making application of the methods straightforward. Topics discussed include maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of equivalence and non-inferiority immunogenicity trial data, analysis of data from vaccine field efficacy trials (including data from studies with recurrent infection data), fitting protection curves to data of challenge or field efficacy studies, and the analysis of vaccine safety data.

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Details

Author: Search for this author Nauta, Jozef
Statement of Responsibility: Jozef Nauta
Year: 2010
Publisher: Berlin, Springer
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Classification: Search for this systematic MA-10, ME-10
Subject type: Search for this subject type Monographien
ISBN: 9783642146909
ISBN (2nd): 3-642-14690-2
Description: XVIII, 153 S.
Tags: Mathematik allgemein; Medizin allgemein
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Language: englisch||
Footnote: Literaturangaben
Media group: Ausleihbestand