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Description

 

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

 

Contents

 

1. Epigenetics: From Phenomenon to Field D.E. Gottschling

2. A Brief History of Epigenetics G. Felsenfeld

3. Overview and Concepts C.D. Allis, T. Jenuwein, and D. Reinberg

4. Epigenetics in Saccharomyces cerevisiae M. Grunstein and S. Gasser

5. Position Effect Variegation, Heterochro-matin Formation, and Gene Silencing in Drosophila S.C.R. Elgin and G. Reuter

6. Fungal Models for Epigenetic Research: Schizosaccharomyces pombe and Neurospora crassa R.C. Allshire and E.U. Selker

7. Epigenetics of Ciliates E. Meyer and D.L. Chalker

8. RNAi and Heterochromatin Assembly R. Martienssen and D. Moazed

9. Epigenetic Regulation in Plants M. Matzke and O. Mittelsten Scheid

10. Chromatin Modifications and Their Mechanism of Action T. Kouzarides and S.L. Berger

11. Transcriptional Silencing by Polycomb Group Proteins U. Grossniklaus and R. Paro

12. Transcriptional Regulation by Trithorax Group Proteins R.E. Kingston and J.W. Tamkun

13. Histone Variants and Epigenetics S. Henikoff and M.M. Smith

14. Epigenetic Regulation of Chromosome Inheritance G.H. Karpen and R.S. Hawley

15. Epigenetic Regulation of the X Chromosomes in C. elegans S. Strome and W.G. Kelly

16. Dosage Compensation in Drosophila J.C. Lucchesi and M.I. Kuroda

17. Dosage Compensation in Mammals N. Brockdorff and B.M. Turner

18. DNA Methylation in Mammals E. Li and A. Bird

19. Genomic Imprinting in Mammals D.P. Barlow and M.S. Bartolomei

20. Germ Line and Pluripotent Stem Cells M.A. Surani and W. Reik

21. Epigenetic Control of Lymphopoiesis M. Busslinger and A. Tarakhovsky

22. Nuclear Transplantation and the Reprogramming of the Genome R. Jaenisch and J. Gurdon

23. Epigenetics and Human Disease H.Y. Zoghbi and A.L. Beaudet

24. Epigenetic Determinants of Cancer S.B. Baylin and P.A. Jones

Appendices

Index