Case Studies in Immunology, Seventh Edition is intended for medical students and undergraduate and graduate students in immunology. It presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. Each case history is preceded by essential scientific facts about the immunological mechanisms of that specific disorder. The cases themselves demonstrate how immunological problems are deconstructed in the clinic and each one is followed by a concise summary of the clinical finding and questions which can serve as discussion points.
The book includes a total of 55 cases and can be used as either a standalone text, review aid, or as a companion to Janeway’s Immunobiology, Ninth Edition and The Immune System, Fourth Edition.
Key Features:
-Concise presentation of basic scientific facts and clinical presentation and diagnosis of immunological disorders.
-Cases are drawn from actual clinical practice and provide open-ended scenarios that leave room for thought and analysis.
-Case study format presents the mechanisms underlying immunological dysfunction and aids in the diagnosis and treatment of immune disorders.
-Discussion questions help students move beyond the stated facts to consider the implications of immunological disorders on other aspects of health and disease.
-Can be used as both a stand-alone review aid or as a companion to Janeway’s Immunobiology, Ninth Edition, and The Immune System, Fourth Edition.
-New topics to this edition include: Channelopathies, T-Cell Signaling Defects, LRBA Deficiency, PI3K Delta, Dock 8 Deficiency, and Increased Susceptibility to Candida Infections.
TOC:
1. X-linked Agammaglobulinemia
2. CD40 Ligand Deficiency
3. Activation-Induced Cytidine Deaminase Deficiency
4. Common Variable Immunodeficiency
5. X-linked Severe Combined Immunodeficiency
6. Adenosine Deaminase Deficiency
7. Omenn Syndrome
8. MHC Class II Deficiency
9. DiGeorge Syndrome
10. Acquired Immune Deficiency Syndrome (AIDS)
11. Graft-Versus-Host Disease
12. MHC Class I Deficiency
13. X-linked Lymphoproliferative Syndrome
14. Hemophagocytic Lymphohistiocytosis
15. Chediak–Higashi Syndrome
16. Wiskott-Aldrich Syndrome
17. Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy (APECED)
18. Immune Dysregulation, Polyendocrinopathy, Enteropathy X-linked Disease
19. Autoimmune Lymphoproliferative Syndrome (ALPS)
20. Hyper IgE Syndrome
21. Ataxia Telangiectasia
22. Warts, Hypogammaglobulinemia, Infections, and Myelokathexis Syndrome (WHIM Syndrome)
23. X-linked Hypohidrotic Ectodermal Dysplasia and Immunodeficiency
24. Interferon-¿ Receptor Deficiency
25. Severe Congenital Neutropenia
26. Chronic Granulomatous Disease
27. Leukocyte Adhesion Deficiency
28. Recurrent Herpes Simplex Encephalitis
29. Interleukin 1 Receptor-Associated Kinase 4 Deficiency
30. Congenital Asplenia
31. Hereditary Angioedema
32. Deficiency of the C8 Complement Component
33. Hereditary Periodic Fever Syndromes
34. Systemic Juvenile Idiopathic Arthritis
35. Rheumatoid Arthritis
36. Systemic Lupus Erythematosus
37. Systemic Lupus Erythematosus
38. Multiple Sclerosis
39. Autoimmune Hemolytic Anemia
40. Myasthenia Gravis
41. Pemphigus Vulgaris
42. Celiac Disease
43. Acute Infectious Mononucleosis
44. Hemolytic Disease of the Newborn
45. Toxic Shock Syndrome
46. Lepromatous Leprosy
47. Allergic Asthma
48. Drug-induced Serum Sickness
49. Contact Sensitivity to Poison Ivy
50. Dedicator of Cytokinesis 8 Deficiency
51. Activated PI3KD Syndrome (APDS)
52. Increased Susceptibility to Candida Infections
53. LPS-Responsive Beige-Like Anchor (LRBA) Deficiency
54. T Cell Signaling Defects
55. Channelopathies