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In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.

 

TOC:

Table of Contents

 

Preface VII

 

Cover Legend IX

 

List of Contributors XI

 

Part One Adaptation of Microbial Metabolism in Host/Pathogen Interaction 1

 

1 Metabolic Adaptation of Human Pathogenic Yersiniae 3

Ann Kathrin Heroven and Petra Dersch*

 

2 Crosstalk between Metabolism and Virulence of Legionella pneumophila 19

Klaus Heuner andWolfgang Eisenreich*

 

3 Metabolism of Intracellular Salmonella enterica 37

Peter Holtk¨otter and Michael Hensel*

 

4 The Human Microbiome in Health and Disease 57

Cian Hill, R. Paul Ross, Catherine Stanton, and Paul W. O’Toole*

 

5 Mechanisms of Dysbiosis in the Inflamed Gut 77

Sebastian E. Winter*

 

6 Strategies for Nutrient Acquisition by Magnaporthe oryzae during the Infection of Rice 93

Andrew J. Foster, George R. Littlejohn, Darren M. Soanes, and Nicholas J. Talbot*

 

Part Two New Inhibitors and Targets of Infectious Diseases 109

 

7 Outer Membrane Proteins as Potential Anti-infective Drug Targets in Mannheimia haemolytica 111

Robert L. Davies*

 

8 Identification of Anti-infective Compounds Using Amoebae 139

Christopher F. Harrison and Hubert Hilbi*

 

9 Stress Biology in Fungi and “Omic” Approaches as Suitable Tools for Analyzing Plant–Microbe Interactions 153

Stefan Jacob* and Alexander Yemelin

 

10 Targeting Plasmids: NewWays to Plasmid Curing 179

Anja Sch¨uffler* and Corinna K ¨ubler

 

11 Regulation of SecondaryMetabolism in the Gray Mold Fungus Botrytis cinerea 201

Muriel Viaud*, Julia Schumacher, Antoine Porquier, and Adeline Simon

 

Index 217