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006 marked the 50th anniversary of the discovery of the human chromosome number, establishing human cytogenetics as a scientific discipline and setting the basis for modern medical genetics.

 

 

 

First Years of Human Chromosomes draws together the ground-breaking work of the main researchers in the key period 1955 to 1960.

 

The book is based on interviews with these researchers and descriptions of the major research findings, giving a strong sense of the excitement and thoughts of those involved. To complete the picture, it also features a CD of the recorded interviews.

 

Contents

 

Preface

 

1. Beginnings: Human chromosomes before 1956

 

2. 46 not 48: The discovery of the human chromosome number, 1956

 

3. 1959: the chromosome basis of Down's syndrome

 

4. The sex chromosomes

 

5. The other autosomal trisomies, 1960

 

6. Chromosomes and leukaemia

 

7. Technology and nomenclature: the next steps,1960

 

8. Later years: the growth of human and clinical cytogenetics

 

9. Conclusions

 

Acknowledgements

 

Appendices:

 

1. Some general historical publications on human cytogentics

 

2. List of those interviewed

 

3. The recordings. Key to excerpts included on the CD

 

4. Audio CD of interviews of early workers in human cytogenetics (attached to back cover)