Branch	Locations	Status	Reservations	Due date	Barcode	Floor plan	Lending note
Branch: Dauerleihe	Locations: NA-110 38	Status: borrowed	Reservations: 0	Due date: 1/1/2199	Barcode: 00297127	Floor plans: Floor plan	Lending note:
Branch: Hauptstelle	Locations: NA-110 38 (2.Ex.)	Status: borrowed	Reservations: 0	Due date: 9/7/2023	Barcode: 00297135	Floor plans: Floor plan	Lending note:

Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sourcFes. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.

 

This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.

 

Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:

 

What are antibiotics?

Where do antibiotics come from?

How do antibiotics work?

Why do antibiotics stop working?

How should our limited inventory of effective antibiotics be addressed?

Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.