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Primary and stem cells

gene transfer technologies and applications

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Year: 2012

Publisher: Hoboken, NJ, Wiley

Media group: Ausleihbestand

available

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Branch	Locations	Status	Reservations	Due date	Barcode	Floor plan	Lending note
Branch: Hauptstelle	Locations: ZB-70 45	Status: available	Reservations: 0	Due date:	Barcode: 00259578	Floor plans: Floor plan	Lending note:

Content

This book describes basic cell engineering methods, emphasizing stem cell applications, and use of the genetically modified stem cells in cell therapy and drug discovery. Together, the chapters introduce and offer insights on new techniques for engineering of stem cells and the delivery of transgenes into stem cells via various viral and non-viral systems. The book offers a guide to the types of manipulations currently available to create genetically engineered stem cells that suit any investigator's purpose, whether it's basic science investigation, creation of disease models and screens, or cells for therapeutic applications.

TOC:

FOREWORD vii

Michele Calos

PREFACE ix

CONTRIBUTORS xi

PART I: CLONING AND GENE DELIVERY 1

1. DNA Assembly Technologies Based on Homologous Recombination 3

Billyana Tsvetanova, Lansha Peng, Xiquan Liang, Ke Li, Jian-Ping Yang, Tony Ho, Josh Shirley, Liewei Xu, Jason Potter, Wieslaw Kudlicki, Todd Peterson, and Federico Katzen

2. Multigene Assembly for Construction of Synthetic Operons: Creation and Delivery of an Optimized All-IN-One Expression Construct for Generating Mouse iPS Cells 19

Takefumi Sone, Yoko Takata, Hiroe Kishine, Taichi Andoh, Fumio Imamoto, and Jonathan D. Chesnut

3. Strategies for the Delivery of Naked DNA 37

Jennifer C. Moore and Ronald P. Hart

PART II: NONINTEGRATING TECHNOLOGIES 49

4. Episomal Vectors 51

Junying Yu

5. Nonintegrating DNA Virus 85

Chris Kemp and David Kuninger

6. Nonintegrating RNA Viruses 103

Noemi Fusaki

7. Protein Delivery 119

Xiao-Jian Han and Kazuhito Tomizawa

PART III: INTEGRATING TECHNOLOGIES 135

8. Sleeping Beauty Transposon-Mediated Stable Gene Delivery 137

Andrew Wilber, Xianzheng Zhou, Xin Huang, Dan S. Kaufman, and R. Scott McIvor

9. Integrating Viral Vectors for Gene Modifications 163

Gemma L. Mendel, Brian Paszkiet, and Rafal P. Witek

10. Bacteriophage Integrases for Site-Specific Integration 199

Bhaskar Thyagarajan

11. Improving Gene Targeting Efficiency in Human Pluripotent Stem Cells 211

Sangyoon Han, Anna McCann, Louise C. Laurent, Jeanne F. Loring, and Ying Liu

PART IV: APPLICATIONS 227

12. Modified Stem Cells as Disease Models and in Toxicology Screening 229

Catharina Ellerstr€om, Peter Sartipy, Raimund Strehl, and Johan Hyllner

13. Screening and Drug Discovery 251

Elizabeth A. Davenport and Robert S. Ames

INDEX 273

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Details

Statement of Responsibility: edited by Uma Lakshmipathy ; Bhaskar Thyagarajan

Year: 2012

Publisher: Hoboken, NJ, Wiley

Links: Standort A002, Google Book Preview

Classification: ZB-70, GE-30, BT-10

Subject type: Monographien

ISBN: 9780470610749

ISBN (2nd): 0-470-61074-3

Description: XIII, 279 S. : Ill., graph. Darst.

Tags: Entwicklung; Differenzierung; Molekulare Genetik; Biotechnologie allgemein

Participating parties: Lakshmipathy, Uma [Hrsg.]; Thyagarajan, Bhaskar [Hrsg.]

Language: englisch||

Footnote: Literaturangaben

Media group: Ausleihbestand

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