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RNA molecules are now extensively used in academic labs and the pharmaceutical industry to probe gene function and validate protein targets for drug discovery. RNA Interference provides a general overview of this rapidly emerging field and for the novice reader, a strong emphasis on issues and aspects that are important to a drug development team. The first part covers the more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), which have proven to be a pharmaceutically more potent form than DNA, and its use and delivery in therapeutics along with manufacturing and delivery aspects. An important text for students and scientists in the biotechnology and pharmaceutical disciplines.

 

Aus dem Inhalt

CONTRIBUTORS.

 

PREFACE.

 

FOREWORD.

 

I. Biology of RNA Interference.

 

1 RNA Interference: What is it? (James A. Birchler).

 

2 Nucleic Acids as Regulatory Molecules (Faqing Huang, C. J. Yu, and Yanlin Guo).

 

3 Use of siRNA Oligonucleotides to Study Gene Function (Kristin A. Wiederholt and Adam N. Harris).

 

4 Genome Scanning by RNA Interference (Roderick L. Beijersbergen and Oliver C. Steinbach).

 

II Development of siRNA for Therapeutic Applications.

 

5 Discovery of New siRNA Delivery Agents (Paul H. Johnson, Diane Frank, Kunyuan Cui, Roger Adami, Harry Wang, Michael Houston, and Steven C. Quay).

 

6 siRNA Delivery Vehicles (Aliasger K. Salem and Mark A. Behlke).

 

7 Interferon, Cytokine Induction and Other Potential In Vivo Toxicities (Adam Judge, Marjorie Robbins, and Ian MacLachlan).

 

8 Application of RNA Interference to Viral Diseases (Ralph A. Tripp and Stephen Mark Tompkins).

 

Index.