Preface
Chapter 1 - Miniaturized Formats for Efficient Liquid Chromatography Mass Spectrometry-Based Proteomics and Therapeutic Development
Gary A. Valaskovic and Neil L. Kelleher
Chapter 2 - Mass Spectrometry Based Drug Screening Assays for Early Phases in Drug Discovery
Marshall M. Siegel
Chapter 3 - ESI-FTICR as a High Throughput Drug Discovery Platform
Kristin A. Sannes-Lowery, Lendell L. Cummins, Shuo Chen, Jared J. Drader and Steven A. Hofstadler
Chapter 4 - Mass Spectrometry Based Proteomic Approaches for Disease Diagnosis and Biomarker Discovery
Thomas P. Conrads, Haleem J. Issaq, Josip S. Blonder, and Timothy D. Veenstra
Chapter 5 - Metabonomic Applications in Toxicity Screening and Disease Diagnosis
John P. Shockcor and Elaine Holmes
Chapter 6 - The Central Role of Mass Spectrometry in Natural Products Discovery
Jeffrey R. Gilbert, Paul Lewer, Dennis O. Duebelbeis, and Andrew W. Carr
Chapter 7 - Application of Mass Spectrometry to Compound Library Generation, Analysis, and Management
Xueheng Cheng and Jill Hochlowski
Chapter 8 - A Combinatorial Process for Drug Discovery
David S. Wagner, Richard W. Wagner, Frank Schoenen, and H. Mario Geysen
Chapter 9 - Application of Technological Advances in Biotransformation Studies
Carmen L. Fern ndez-Metzler, Raju Subramanian and Richard C. King
Chapter 10 - Applications of Mass Spectrometry for the Characterization of Reactive Metabolites of Drugs in Discovery
Jim Wang, Jack Wang, Margaret Davis, William DeMaio, JoAnn Scatina and Rasmy Talaat
Chapter 11 - Advances in High-Throughput Quantitative Drug Discovery Bioanalysis
Bradley L. Ackermann, Michael J. Berna and Anthony T. Murphy
Chapter 12 - New Strategies for the Implementation and Support of Bioanalysis In a Drug Metabolism Environment
Walter A. Korfmacher
Chapter 13 - An Integrated LC/MS Strategy for Preclinical Candidate Optimization
Jonathan L. Josephs and Mark Sanders
Chapter 14 - New Approaches for Method Development and Purification in Lead Optimization
Yining Zhao and David Semin
Chapter 15 - High Throughput Metabolic and Physicochemical Property Analysis: Strategies and Tactics for Impact on Drug Discovery Success
Edward H. Kerns and Li Di
Chapter 16 - Organ Perfusion and Mass Spectrometry
C. Gerald Curtis, Ben Chien, David Bar-Or, and Kumar Ramu
Chapter 17 - Sample Preparation for Drug Discovery Bioanalysis
David A. Wells
Chapter 18 - Automation
Statement of Responsibility:
Mike S. Lee
Year:
2005
Publisher:
New York [u.a.], Wiley
Articles:
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Classification:
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SP-20, ME-20
ISBN:
047146127X
Description:
XVII, 550 S. ; graph. Darst.
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Language:
englisch||
Footnote:
Literaturangaben
Media group:
Ausleihbestand