CONTENTS
Contributors ·
Foreword ·
Preface ·
Introduction ·
Prologue ·
I. Tetracyclines and Resistance
Introduction: Michael N. Alekshun
1. Tetracycline Resistance: Efflux, Mutation, and Other Mechanisms · 3
Frederic M. Sapunaric, Mila Aldema-Ramos, and Laura M. McMurry
2. Tetracycline Resistance Due to Ribosomal Protection Proteins · 19
Marilyn C. Roberts
3. Discovery and Industrialization of Therapeutically Important
Tetracyclines · 29
Mark L. Nelson and Steven J. Projan
II. Single Antimicrobial Resistance Mechanisms
Introduction: Patrick F. McDermott
4. Fluoroquinolone Resistance · 41
Jordi Vila
5. ?-Lactam Resistance in the 21st Century · 53
George Jacoby and Karen Bush
6. Macrolide, Lincosamide, Streptogramin, Ketolide, and Oxazolidinone Resistance · 66
Marilyn C. Roberts and Joyce Sutcliff
7. Aminoglycoside Resistance Mechanisms · 85
David D. Boehr, Ian Moore, and Gerard D. Wright
8. Glycopeptide Resistance in Enterococci · 101
Florence Depardieu and Patrice Courvalin
9. Phenicol Resistance · 124
Stefan Schwarz and David G. White
III. Multiple Antimicrobial Resistance Mechanisms
Introduction: Patrick F. McDermott
10. Multiple Antimicrobial Resistance · 151
Anthony M. George
11. Metal Resistance Loci of Bacterial Pathogens · 165
Anne O. Summers
12. Biocides and Resistance · 174
Bonnie Marshall, Laura M. McMurry, and Merri C. Moken
13. The Nexus of Oxidative Stress Responses and Antibiotic Resistance
Mechanisms in Escherichia coli and Salmonella · 191
Bruce Demple
14. The mar Locus · 198
Thamarai Schneiders, Herbert Haechler, and William Yan
15. The mar Regulon · 209
Teresa M. Barbosa and Pablo J. Pomposiello
16. Identification of Mar Mutants among Clinical Bacterial Isolates · 224
JoAnn Dzink-Fox and Margret Oethinger
17. Structure and Function of MarA and Its Homologs · 235
Robert G. Martin and Judah L. Rosner
18. Function and Structure of MarR Family Members · 247
Michael N. Alekshun and James F. Head
19. Role, Structure, and Function of Multidrug Efflux Pumps in Gram-Negative Bacteria · 261
Hiroshi Nikaido
20. Role of Multidrug Efflux Pumps in Gram-Positive Bacteria · 275
Glenn W. Kaatz
IV. Antimicrobial Resistance in Select Pathogens
Introduction: David G. White
21. Advances in Vancomycin Resistance: Research in Staphylococcus aureus · 289
Keiichi Hiramatsu, Maria Kapi, Yutaka Tajima, Longzhu Cui,
Suwanna Trakulsomboon, and Teruyo Ito
22. Enterococcus · 299
Roland Leclercq and Patrice Courvalin
23. Streptococcus pneumoniae · 314
Joyce Sutcliff and Marilyn C. Roberts
24. Helicobacter and Campylobacter · 330
Patrick F. McDermott and Diane E. Taylor
25. Anaerobes · 340
Isabelle Podglajen, Jacques Breuil, and Ekkehard Collatz
26. Pseudomonas aeruginosa · 355
Keith Poole
27. Antibiotic Resistance in Salmonella and Shigella · 367
E. J. Threlfall
28. Antibiotic Resistance in Escherichia coli · 374
Mark A. Webber and Laura J. V. Piddock
29. Epidemiology and Treatment Options for Select Community-Acquired and Nosocomial Antimicrobial-Resistant Pathogens · 387
John E. Gustafson and John D. Goldman
30. Drug-Resistant Falciparum Malaria: Mechanisms, Consequences, and Challenges · 401
Karen Hayton, Rick M. Fairhurst, Bronwen Naudé, Xin-zhuan Su, and Thomas E. Wellems
31. Antimicrobial Susceptibility Testing of Bacterial Agents of Bioterrorism: Strategies and Considerations · 414
Fred C. Tenover
V. The Ecology and Fitness of Drug Resistance
Introduction: David G. White
32. Fitness Traits in Soil Bacteria · 425
Fabrice N. Gravelat, Stephen R. Strain, and Mark W. Silby
33. Ecology of Antibiotic Resistance Genes · 436
Abigail A. Salyers, Hera Vlamakis, and Nadja B. Shoemaker
34. Resistance in the Food Chain and in Bacteria from Animals:
Relevance to Human Infections · 446
Vincent Perreten
35. Antimicrobial Use in Plant Agriculture · 465
Anne K. Vidaver
VI. Drug Resistance in Cancer Cells
Introduction: Michael N. Alekshun
36. Overview of Mechanisms of Resistance to Anticancer Agents · 473
Michael P. Draper, Graham K. Jones, Christopher J. Gould, and David E. Modrak
37. Development of Resistance to Anticancer Agents · 500
David E. Modrak, Graham Jones, and Michael P. Draper
VII. Policy, Education, and Exploration
Introduction: Michael N. Alekshun
38. The Birth of the Alliance for the Prudent Use of Antibiotics (APUA) · 517
Ellen Koenig
39. Alliance for the Prudent Use of Antibiotics: Scientific Vision and Public Mission · 519
Kathleen T. Young and Thomas F. O'Brien
40. Antimicrobial Use in Animals in the United States: Developments in Policy and Practice · 528
Stephen J. DeVincent and Christina Viola
41. From Perplexing Proteins to Paratek Pharmaceuticals: One Scientific Front Forged by Stuart B. Levy · 537
Mark L. Nelson and S. Ken Tanaka
Afterword. Learning and Teaching: a Personal Reflection · 551
Julian Davies
Index · 555