Janeway’s Immunobiology is a textbook for students studying immunology at the undergraduate, graduate, and medical school levels. As an introductory text, students will appreciate the book’s clear writing and informative illustrations, while advanced students and working immunologists will value its comprehensive scope and depth. Janeway’s Immunobiology presents immunology from a consistent point of view throughout—that of the host’s interaction with an environment full of microbes and pathogens.
The Ninth Edition has been thoroughly revised bringing the content up-to-date with significant developments in the field, especially on the topic of innate immunity, and improving the presentation of topics across chapters for better continuity.
New in the Ninth Edition:
Now organized around the concept of modular immune responses, combining innate and adaptive immunity into effector modules and explaining the integration of the innate and adaptive immune response.
Updated with the latest developments on innate lymphoid cells and innate sensing mechanisms, including cycling GMP-SMP synthase (cGAS) and activation of the STING pathway.
Incorporates the new mechanisms of class switch recombination involving RNA guides for AID.
Includes an expanded, updated coverage of CD4 T cell subsets, including an in-depth handling of follicular helper T cells and their role in B cell class switching and affinity maturation.
Improved coverage of chemokine networks and their role in coordinating immunity.
Includes new content on cytoskeletal reorganization and integrin activation in antigen receptor signaling and expanded coverage on Akt and mTOR signaling.
Revised and updated sections on mechanisms of immune evasion by pathogens and HIV/AIDS.
Updated and more detailed consideration of mechanisms of immunemediated disease.
Expanded coverage of cancer immunotherapy, including chimeric antigen receptor T cell (CAR T cell) therapy.
Comprehensive update to Appendix I: The Immunologist’s Toolbox, with the addition of many new techniques, including mass spectrometry, in vivo administration of antibodies, RNAi, and the CRISPR/Cas9 system.
Illustration program has been thoroughly updated with over 100 new figures and improved with newer and better images of protein structures and micrographs.
Completely updated end-of-chapter questions in a variety of types that review each chapter’s concepts.
TOC:
Part I: An Introduction to Immunobiology and Innate Immunity
Chapter 1: Basic Concepts in Immunology
Chapter 2: Innate Immunity: The First Lines of Defense
Chapter 3: The Induced Responses of Innate Immunity
Part II: The Recognition of Antigen
Chapter 4: Antigen Recognition by B-cell and T-cell Receptors
Chapter 5: The Generation of Lymphocyte Antigen Receptors
Chapter 6: Antigen Presentation to T Lymphocytes
Part III: The Development of Mature Lymphocyte Receptor Repertoires
Chapter 7: Lymphocyte Receptor Signaling
Chapter 8: The Development and of B and T Lymphocytes
Part IV: The Adaptive Immune Response
Chapter 9: T Cell-Mediated Immunity
Chapter 10: The Humoral Immune Response
Chapter 11: Integrated Dynamics of Innate and Adaptive Immunity
Chapter 12: The Mucosal Immune System
Part V: The Immune System in Health and Disease
Chapter 13: Failures of Host Defense Mechanisms
Chapter 14: Allergy and Allergic Diseases
Chapter 15: Autoimmunity and Transplantation
Chapter 16: Manipulation of the Immune Response