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Molecular Biology of Assemblies and Machines presents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology, and microbiology, and will also appeal to those in chemistry, immunology, and medicine.

 

Essentially all major biological activities are performed by assemblies of macromolecules (proteins, RNA, and DNA) acting in concert. These assemblies are dynamic and many are endowed with machine-like properties. This unique book explores the molecular mechanisms employed at the critical level between individual macromolecules and cells and organelles.

Features

 

• Uses vivid illustrations to convey the ways in which macromolecular structures assemble and how they interact with other complexes and organelles in the cell.

• Written as the go-to reference for advanced students and researchers in biochemistry, molecular biology, biophysics, cell biology, chemistry, structural biology, immunology, microbiology, and medicine.

• Features a searchable glossary online, as well as flashcards, for testing student vocabulary.

• Chapters contain boxes exploring difficult concepts in more depth and end with a curated list of references for further reading.

• Two appendices provide a “Field Guide” to commonly encountered protein folds and descriptions of the main methods currently used in the practice of structural biology.

TOC:

1. The Machines and Assemblies of Life

2. Chromatin

3. DNA Replication

4. DNA Repair and Recombination

5. Transcription

6. Protein Synthesis and Folding

7. Intracellular Proteolysis: Protein Quality Control and Regulatory Turnover

8. Assembly of Viruses

9. Multienzyme Complexes: Catalytic Nanomachines

10. Transport

11. Connectivity and Communication

12. Signaling

13. The cell cycle and cell death

14. Motility

15. Bioenergetics

16. Membrane Channels and Transporters

17. Complexes of the Immune System