Bacterial pathogens cause numerous human diseases. This collection from Cold Spring Harbor Perspectives in Medicine surveys the spectrum of bacterial pathogens from Salmonella and Shigella to Heliobacter pylori. It examines the basic biology of these parasites, their virulence mechanisms and the host’s response to infection. The effectiveness of antibiotics and vaccine strategies are also covered, along with the novel antimicrobial therapies that are being developed.
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Contents
Preface
PART 1: MODEL SYSTEMS
Bartonella and Brucella—Weapons and Strategies for Stealth Attack
Houchaima Ben-Tekaya, Jean-Pierre Gorvel, and Christoph Dehio
Chlamydial Intracellular Survival Strategies
Robert J. Bastidas, Cherilyn A. Elwell, Joanne N. Engel, and Raphael H. Valdivia
In Vitro and In Vivo Model Systems for Studying Enteropathogenic Escherichia coli Infections
Robyn J. Law, Lihi Gur-Arie, Ilan Rosenshine, and B. Brett Finlay
Genome Dynamics in Legionella: The Basis of Versatility and Adaptation to Intracellular Replication
Laura Gomez-Valero and Carmen Buchrieser
Mechanisms of Francisella tularensis Intracellular Pathogenesis
Jean Celli and Thomas C. Zahrt
Echoes of a Distant Past: The cag Pathogenicity Island of Helicobacter pylori
Nicola Pacchiani, Stefano Censini, Ludovico Buti, and Antonello Covacci
Helicobacter and Salmonella Persistent Infection Strategies
Denise M. Monack
Entry of Listeria monocytogenes in Mammalian Epithelial Cells: An Updated View
Javier Pizarro-Cerdá, Andreas Kühbacher, and Pascale Cossart
Pathogenesis of Meningococcemia
Mathieu Coureuil, Olivier Join-Lambert, Hervé Lécuyer, Sandrine Bourdoulous, Stefano Marullo, and Xavier Nassif
The Pneumococcus: Epidemiology, Microbiology, and Pathogenesis
Birgitta Henriques-Normark and Elaine I. Tuomanen
The Inside Story of Shigella Invasion of Intestinal Epithelial Cells
Nathalie Carayol and Guy Tran Van Nhieu
PART 2: GENERAL CONCEPTS AND MECHANISMS
RNA-Mediated Regulation in Pathogenic Bacteria
Isabelle Caldelari, Yanjie Chao, Pascale Romby, and Jörg Vogel
Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control
Steven T. Rutherford and Bonnie L. Bassler
Mechanisms and Biological Roles of Contact-Dependent Growth Inhibition Systems
Christopher S. Hayes, Sanna Koskiniemi, Zachary C. Ruhe, Stephen J. Poole, and David A. Low
Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era
Maria Kostakioti, Maria Hadjifrangiskou, and Scott J. Hultgren
General Aspects and Recent Advances on Bacterial Protein Toxins
Emmanuel Lemichez and Joseph T. Barbieri
Epigenetics and Bacterial Infections
Hélène Bierne, Mélanie Hamon, and Pascale Cossart
Concepts and Mechanisms: Crossing Host Barriers
Kelly S. Doran, Anirban Banerjee, Olivier Disson, and Marc Lecuit
Host Specificity of Bacterial Pathogens
Andreas Bäumler and Ferric C. Fang
A Genome-Wide Perspective of Human Diversity and Its Implications in Infectious Disease
Jérémy and Lluis Quintana-Murci
PART 3: THERAPEUTICS
Vaccines, Reverse Vaccinology, and Bacterial Pathogenesis
Isabel Delany, Rino Rappuoli, and Kate L. Seib
Probiotics: Properties, Examples, and Specific Applications
Judith Behnsen, Elisa Deriu, Martina Sassone-Corsi, and Manuela Raffatellu
Therapeutic and Prophylactic Applications of Bacteriophage Components in Modern Medicine
Sankar Adhya, Carl R. Merril, and Biswajit Biswas
Index