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Protein-protein interactions as new drug targets

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Year: 2008
Publisher: Berlin [u.a.], Springer
Series: Handbook of experimental pharmacology; 186
Media group: Ausleihbestand
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Branch: Hauptstelle Locations: NA-30 175 Status: available Reservations: 0 Due date: Barcode: 00191981 Floor plans: Floor plan Lending note:

Content

Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions.
 
This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
Table of contents
 
Preface.- Part I. Organization of Scaffolds.- Part II. Scaffolding Proteins and Cellular Signalling.- Part III. Cell Type-Specific Anchoring.- Part IV. Interference With Protein-Protein Interaction Sites as a New Pharmacological Concept.

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Statement of Responsibility: Enno Klussmann ; John Scott editors
Year: 2008
Publisher: Berlin [u.a.], Springer
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Classification: Search for this systematic NA-30, ME-30
Subject type: Search for this subject type Monographien
ISBN: 9783540728429
ISBN (2nd): 3-540-72842-2
Description: XV, 512 S. : Il.., graph. Darst.
Series: Handbook of experimental pharmacology; 186
Tags: Proteine; Pharmazie
Participating parties: Search for this character Klussmann, Enno [Hrsg.]; Scott, John [Hrsg.]
Language: englisch||
Footnote: Literaturangaben
Media group: Ausleihbestand