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Enzybiotics, by using enzymes to fight bacteria, offer a novel and promising new way to combat infectious diseases. This book presents the state-of-the-art and therapeutic potential of enzybiotics, with a stress on therapeutic applications. The coverage offers a unique combination of medicinal chemistry, microbiology, genetics, and biochemistry. It also addresses the timely topic of bacterial resistance to antibiotics, and provides readers with a novel angle to study and combat infectious diseases.

 

Aus dem Inhalt

PREFACE.

 

CONTRIBUTORS.

 

1 ENZYBIOTICS AND THEIR POTENTIAL APPLICATIONS IN MEDICINE (Jan Borysowski and Andrzej Górski).

 

2 ADVANTAGES AND DISADVANTAGES IN THE USE OF ANTIBIOTICS OR PHAGES AS THERAPEUTIC AGENTS (Patricia Veiga-Crespo and Tomas G. Villa).

 

3 ENZYBIOTICS AS SELECTIVE KILLERS OF TARGET BACTERIA (Juan C. Alonso and Marcelo E. Tolmasky).

 

4 PHYLOGENY OF ENZYBIOTICS (Patricia Veiga-Crespo and Tomas G. Villa).

 

5 BACTERIOPHAGE LYSINS: THE ULTIMATE ENZYBIOTIC (Vincent A. Fischetti).

 

6 BACTERIOPHAGE HOLINS AND THEIR MEMBRANEDISRUPTING ACTIVITY (María Gasset).

 

7 ANTI-STAPHYLOCOCCAL LYTIC ENZYMES (Jan Borysowski and Andrzej Górski).

 

8 MEMBRANE-TARGETED ENZYBIOTICS (María Gasset).

 

9 DESIGN OF PHAGE COCKTAILS FOR THERAPY FROM A HOST RANGE POINT OF VIEW (Lawrence D. Goodridge).

 

10 IDENTIFYING PHAGE LYTIC ENZYMES: PAST, PRESENT, AND FUTURE (Jonathan E. Schmitz, Raymond Schuch, and Vincent A. Fischetti).

 

11 USE OF GENETICALLY MODIFIED PHAGES TO DELIVER SUICIDAL GENES TO TARGET BACTERIA (Lawrence D. Goodridge).

 

CONCLUDING REMARKS: THE FUTURE OF ENZYBIOTICS (Patricia Veiga-Crespo and Tomas G. Villa).

 

INDEX.