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The family of aspartic acid proteases is described from a drug developer's perspective. Contains numerous case studies from recently developed protease drugs.

 

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OVERVIEW OF ASPARTIC ACID PROTEASES

Introduction to the Aspartic Proteases Family

Aspartic Acid Proteases, Structure, Function and Inhibition

Human Aspartic Proteinases

Structure-based Drug Design Strategies for the Inhibition of Aspartic Acid Proteases

 

HIV-1 PROTEASE FOR THE TREATMENT OF HIV/AIDS

HIV-1 Protease: Role in Viral Replication, Protein-Ligand X-ray Crystal Structures and Inhibitor Design

First generation FDA Approved HIV protease inhibitors

Second-Generation Approved HIV Protease Inhibitors for Treatment of HIV/AIDS

Design, Conception and Clinical Development of Darunavir, a HIV-1 Protease Inhibitor to Combat Drug Resistance

Development of Protease Inhibitors and Challenges to Drug-Resistance of HIV-1

 

RENIN FOR TREATMENT OF HYPERTENSION

Discovery and Development of Aliskiren, the First-in-Class Direct Renin Inhibitor for the Treatment of Hypertension

Evolution of Diverse Classes of Renin Inhibitors Through the Years

 

GAMMA-SECRETASE FOR TREATMENT OF ALZHEIMER'S DISEASE

Chemistry and Biology of gamma-Secretase as a Possible Target for Alzheimer's Disease

Gamma-Secretase Inhibition: An overview of Development of Inhibitors for Alzheimer's Disease

 

BETA-SECRETASE FOR TREATMENT OF ALZHEIMER'S DISEASE

BACE - An (Almost) Perfect Target for Staving Off Alzheimer's Disease

Discovery of Memapsin 2 (BACE1), Design of Inhibitors and Drug-design Tools

Peptidomimetic BACE1 Inhibitors for Treatment of Alzheimer's Disease: Design and Evolution

Non-Peptide BACE1 Inhibitors: Design and Synthesis

 

PLASMEPSINS AND OTHER ASPARTIC PROTEASES AS DRUG TARGETS

The Plasmepsin Family as Antimalarial Drug Targets

Design and Synthesis of Plasmepsin Inhibitors for Treatment of Malaria

Fungal aspartic proteases as possible therapeutic targets