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As the major structural component of cell membranes, lipids not only serve as barriers but also play active roles in cellular function. The fission and fusion of lipid membranes underlie the majority of protein trafficking in cells. Lipids are also critical in signal transduction; the interconversion of membrane-localized and soluble species is central to numerous signaling pathways that connect cell-surface receptors with intracellular effectors.

 

Written and edited by experts in the field, this volume provides a comprehensive review of lipid biology. The contributors explore the synthesis, metabolism, and distribution of lipid species in the cell; the composition of lipid rafts and their roles in protein trafficking and signaling; and the biophysical behavior of lipids and membranes. They also discuss models and techniques to study lipid dynamics and to characterize cellular lipidomes.

 

Including discussions of diseases in which lipids play a role and the functions of lipids in virus replication, this volume is an indispensable reference for biochemists, cell and molecular biologists, and biophysicists interested in lipid biology.

Contents

Membrane Organization and Lipid Rafts

Kai Simons and Julio L. Sampaio

Shotgun Lipidomics on High Resolution Mass Spectrometers

Dominik Schwudke, Kai Schuhmann, Ronny Herzog, Stefan R. Bornstein, and Andrej Shevchenko

Model Answers to Lipid Membrane Questions

Ole G. Mouritsen

Phase Separation in Lipid Membranes

Frederick A. Heberle and Gerald W. Feigenson

Lipid Polymorphisms and Membrane Shape

Vadim A. Frolov, Anna V. Shnyrova, and Joshua Zimmerberg

Curvature-Driven Lipid Sorting in Biomembranes

Andrew Callan-Jones, Benoit Sorre, and Patricia Bassereau

Lipid Simulations: A Perspective on Lipids in Action

Ilpo Vattulainen and Tomasz Rog

Fluorescence Techniques to Study Lipid Dynamics

Erdinc Sezgin and Petra Schwille

Dynamic Transbilayer Lipid Asymmetry

Gerrit van Meer

Glycosphingolipid Functions

Clifford A. Lingwood

Regulation of Cholesterol and Fatty Acid Synthesis

Jin Ye and Russell A. DeBose-Boyd

Distribution and Functions of Sterols and Sphingolipids

J. Thomas Hannich, Kyohei Umebayashi, and Howard Riezman

Phosphoinositides in Cell Architecture

Annette Shewan, Dennis J. Eastburn, and Keith Mostov

Specificity of Intramembrane Protein–Lipid Interactions

Francesc-Xabier Contreras, Andreas Max Ernst, Felix Wieland, and Britta Brügger

Synthesis and Biosynthetic Trafficking of Membrane Lipids

Tomas Blom, Pentti Somerharju, and Elina Ikonen

Lipid-Mediated Endocytosis

Helge Ewers and Ari Helenius

Not Just Fat: The Structure and Function of the Lipid Droplet

Toyoshi Fujimoto and Robert G. Parton

Lysosomal Lipid Storage Diseases

Heike Schulze and Konrad Sandhoff

Role of Lipids in Virus Replication

Maier Lorizate and Hans-Georg Kräusslich

Index