Infections by RNA viruses represent a significant cause of illness and death in vertebrates. Specifically in humans, RNA virus infections are responsible for a spectrum of significant acute, chronic, and emerging infections. This volume provides a comprehensive survey of the most recent discoveries in this field, suggests important areas of future research, and highlights issues in need of further investigation. With chapters written by many of the world’s leading investigators, this volume represents a landmark publication in this field for researchers and clinicians.
This volume is arranged around the belief that a careful examination of the early host responses to these RNA virus infections, as well as of the mechanisms adopted by these viruses to evade host antiviral responses, will provide a platform of knowledge that will lead to the development of more effective methods for controlling the spread of RNA viruses or modifying their disease course.
Divided into two major sections, this volume synthesizes recent findings in this fast-moving field while also reviewing accepted knowledge. The first part focuses on the antiviral signaling pathways in the host, including specific pattern recognition receptors (PRRs) and how these cellular alarms signal the innate immune response. The second section examines the ways in which specific major RNA virus families interact with, activate, and elude these signaling pathways and responses. Taken together, this volume provides a timely summary of the latest knowledge and points to areas for further research.
Table of Contents
I. Introduction
1.Introduction and Overview, Allan R. Brasier, Adolfo Garcia-Sastre, and Stanley M. Lemon
II. Antiviral Signaling Pathways and Their Contributions to Virus Control and Pathogenesis
2.Role of Toll-Like Receptors in the Innate Immune Response to RNA Viruses, Sinead E. Keating and Andrew G. Bowie
3. Cytoplasmic Pattern Receptors and Signaling in Viral Infections, Osamu Takeuchi and Shizuo Akira
4. Mitochondrial Antiviral Signaling, Vijay G. Bhoj and Zhijian J. Chen
5. Interferon Regulatory Factors and the Atypical IKK-Related Kinases TBK1 and IKK[e]: Essential Players in the Innate Immune Response to RNA Virus Infection, Meztli Arguello, Suzanne Paz, and John Hiscott
6. Jak-Stat Pathway in Response to Virus Infection, Joan E. Durbin
7. Interferons and Antiviral Action, Christine L. White and Ganes C. Sen
8. The Nuclear Factor-[k]B Transcription Factor Pathway, Amer A. Beg and Xingyu Wang
9. The Nuclear Factor-[k]B Signaling Network: Insights from Systems Approaches, Allan R. Brasier
10. Type I Interferon Signaling in Shaping Cellular Innate and Adaptive Immunity to Viral Infection, Christine A. Biron
11. Biological Impact of Type I Interferon Induction Pathways beyond Their Antivirus Activity, Bahram Razani, Arash Shahangian, Beichu Guo, and Genhong Cheng
12. Human Genetic Factors Involved in Viral Pathogenesis, Lennart Svensson and Elin Kindberg
III. Activation and Evasion of Host Antiviral Signaling Pathways by RNA Viruses
13. RNA Virus Families: Distinguishing Characteristics, Differences, and Similarities, Peter W. Mason and Frank Scholle
14. Rhabdoviruses and Mechanisms of Type I Interferon Antagonism, Krzysztof Brzozka and Karl-Klaus Conzelmann
15. Filoviruses, Christopher F. Basler
16. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, Antonella Casola, Xiaoyong Bao, Allan R. Brasier, and Roberto P. Garofalo
17. Suppression of Innate Immunity by Orthomyxoviruses, Randy A. Albrecht and Adolfo Garcia-Sastre
18. Bunyaviruses and Innate Immunity, Friedemann Weber and Richard M. Elliott
19. Arenaviruses, Juan C. de la Torre
20. Regulation of Innate Immunity by the Flaviviridae, Brenda L. Fredericksen and Michael Gale, Jr.
21. Evasion of Innate Host Antiviral Defenses by Picornaviruses, Stanley M. Lemon
22. Togaviruses, William B. Klimstra and Kate D. Ryman
23. Coronaviruses and Arteriviruses, Krishna Narayanan and Shinji Makino
24. Caliciviridae and Astroviridae, Susana Guix and Mary K. Estes
25. Innate Immune Responses Elicited by Reovirus and Rotavirus, Barbara Sherry, John T. Patton, and Terence S. Dermody
IV. Summary and Perspectives
26. Summary and Perspectives, Allan R. Brasier, Adolfo Garcia-Sastre, and Stanley M. Lemon