Table of Contents
I. General Principles
1. Fungal Molecular Pathogenesis: What Can It Do and Why Do We Need It? John R. Perfect and Arturo Casadevall
2. Sex, MAT, and the Evolution of Fungal Virulence, James A. Fraser and Joseph Heitman
3. Post-Genomic Strategies for Genetic Analysis: Insight from Saccharomyces cerevisiae and Candida albicans, Clarissa J. Nobile and Aaron P. Mitchell
4. Candida albicans Hypha Formation and Virulence, Paula Sundstrom
5. The Conversion from Classical Studies in Fungal Pathogenesis to the Molecular Era, Kyung J. Kwon-Chung and Brian L. Wickes
6. Mating and Parasexual Genetics in Candida albicans, Matthew Miller and Alexander Johnson
7. The Mating-Type Locus and Mating of Candida albicans and Candida glabrata, David R. Soll
8. Evolution of Human Pathogenic Fungi: Phylogenies and Species, John W. Taylor
9. Establishment of Cell Identity in Pathogenic Fungi, Christina M. Hull
10. Signal Transduction in the Interactions of Fungal Pathogens and Mammalian Hosts, Malcolm Whiteway and Catherine Bachewich
11. Function and Regulation of Adhesin Gene Families in Saccharomyces cerevisiae, Candida albicans, and Candida glabrata, Irene Castaño, Alejandro De Las Peñas, and Brendan P. Cormack
12. Fungal Biofilms: Agents of Disease and Drug Resistance, Gordon Ramage, Mahmoud A. Ghannoum, and José L. López-Ribot
13. Molecular Basis of Fungal Adherence to Endothelial and Epithelial Cells, Scott G. Filler, Donald C. Sheppard, and John E. Edwards, Jr.
14. Molecular Principles of Antifungal Drug Resistance, Dominique Sanglard and Theodore C. White
II. Model Systems: Heterologous Hosts, Model Pathogens, and Fungal-Bacterial Interactions
15. Heterologous Hosts and the Evolution and Study of Fungal Pathogenesis, Eleftherios Mylonakis, Stephen B. Calderwood, and Frederick M. Ausubel
16. Amoeba and Slime Mold: Hosts of Virulence Evolution, Arturo Casadevall
17. Aspergillus nidulans: a Model for Elucidation of Aspergillus fumigatus Secondary Metabolism, Nancy Keller
18. Saccharomyces cerevisiae: an Emerging and Model Pathogenic Fungus, John H. McCusker
19. Fungal-Bacterial Interactions, Deborah A. Hogan and Roberto Kolter
20. Amphibian Chytridiomycosis as an Emerging Infectious Disease of Wildlife: What Can We Learn from the Earliest Diverging Fungi? Timothy Y. James and Rytas Vilgalys
III. Specific Pathogens
21. Cryptococcus neoformans: a Sugar-Coated Killer, John R. Perfect
22. Towards a Molecular Understanding of Candida albicans Virulence, Frank C. Odds, Neil A. R. Gow, and Alistair J. P. Brown
23. Molecular Determinants of Histoplasma capsulatum Pathogenesis, Jon P. Woods
24. Molecular Determinants of Virulence in Aspergillus fumigatus, Judith C. Rhodes and Axel A. Brakhage
25. Pathogenesis of Pneumocystis, A. George Smulian and Melanie T. Cushion
26. Virulence Mechanisms of Coccidioides, Garry T. Cole, Jianmin Xue, Kalpathi Seshan, Priscila Borra, Ricardo Borra, Eric Tarcha, Ruth Schaller, Jie-Juen Yu, and Chiung-Yu Hung
27. Blastomyces dermatitidis Cell Surface Determinants and Their Application in Vaccine Development, Bruce Klein
28. Virulence Factors in Black Molds with Emphasis on Melanin, Chitin, and Wangiella as a Molecularly Tractable Model, Paul J. Szaniszlo
29. Zygomycetes as Agents of Infectious Disease in Humans, Ashraf S. Ibrahim and Brad Spellberg
30. Signaling Pathways in the Dimorphic Human Fungal Pathogen Penicillium marneffei, Alex Andrianopoulos and Sophie Zuber
IV. The Host
31. Innate Humoral Immunity to Fungi, Thomas R. Kozel
32. Innate and Acquired Cellular Immunity to Fungi, Luigina Romani
33. Acquired Antibody-Mediated Immunity to Fungi, Liise-Anne Pirofski and Arturo Casadevall
34. Site-Specific Mucosal Immunity to Fungi: Lessons Learned from Candida albicans Applied to Other Fungi, Paul L. Fidel, Jr., and Beatriz Finkel-Jimenez
35. Intracellular Pathogenesis of Histoplasma capsulatum, Simon L. Newman
36. Interactions of Immune Cells with the Facultative Intracellular Pathogen Cryptococcus neoformans, Lauren E. Yauch and Stuart M. Levitz
37. Fungal Interactions with Leukocytes, Mairi C. Noverr, Dennis M. Lindell, Galen B. Toews, and Gary B. Huffnagle
38. Fungal Vaccine Development, Joshua D. Nosanchuk and George S. Deepe, Jr.
39. Molecular Immunopathogenesis of Innate Host Defense against Chronic Disseminated (Hepatosplenic) Candidiasis, Thomas J. Walsh, Emmanuel Roilides, Karoll Cortez, and Caron Lyman
V. Future Directions
40. Studying Fungal Virulence Using Genomics, Michael C. Lorenz
41. Future of Functional Genomics of Histoplasma capsulatum, Anita Sil and Lena Hwang
42. Functional Genomic Approaches to Fungal Pathogenesis, Drug Target Validation, and Antifungal Drug Discovery, Ainslie B. Parsons, Howard Bussey, and Charles Boone
43. Genetic and Proteomic Analysis of Fungal Virulence, Jennifer K. Lodge and Michael C. Lorenz
44. Genomic Perspectives on the Fungal Kingdom, Jason E. Stajich and Fred S. Dietrich