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Table of Contents

 

Introduction

 

Section 1. Pathogenesis of Tuberculosis

 

* 1. Overview

* 2. Stages in the Pathogenesis of Human and Rabbit Tuberculosis

* 3. Types of Human Pulmonary Tuberculosis

* 4. Liquefaction of Caseous Foci and Cavity Formation

 

Section 2. Immunology of Tuberculosis

 

* 5. Delayed-Type Hypersensitivity, Cell-Mediated Immunity, and Antibodies in Tuberculosis

* 6. Macrophages and Other Cells in Tuberculosis Lesions

 

Section 3. Tuberculous Lesions

 

* 7. Structural Components of Tuberculous Lesions

* 8. Microvascular Density in Tuberculosis Lesions

* 9. Early Pulmonary Lesions in Rabbits

* 10. Macrophage Turnover, Division, and Activation in Tuberculosis Lesions

* 11. Lurie's Pulmonary Tubercle-Count Method

 

Section 4. Tuberculosis in Rabbits and Other Common Laboratory Animals

 

* 12. Natural Airborne Infection

* 13. Response of Rabbits to Inhaled Tubercle Bacilli Including BCG

* 14. Characteristics of Resistance and Susceptibility to Tuberculosis in Lurie's Inbred Rabbit

* 15. Comparisons of Tuberculosis in Rabbits, Mice, and Guinea Pigs

 

Section 5. Effects of Hormones and X-Irradiation on Tuberculosis

 

* 16. Effects of Cortisone and Adrenocorticotropic Hormone on Tuberculosis

* 17. Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis

* 18. Effects of Whole-Body X-Irradiation on Tuberculosis

 

Section 6. Cytokines and Vascular Adhesion Molecules in Tuberculous Lesions

 

* 19. Cytokine Production in Primary BCG Lesions

* 20. Cytokine Production in Reinfection BCG Lesions and in Tuberculin Reactions

* 21. Vascular Adhesion Molecules in Tuberculous Lesion

 

Section 7. Tuberculosis Vaccines

 

* 22. Principles and Guidelines for Developing Better Tuberculosis Vaccines

* 23. Characteristics of Rabbit BCG Lesions and Efficacies of BCG and Mycobacterium microti Vaccines

 

Section 8. Past, Present, and Future

 

* 24. Summary and Conclusions

* 25. Suggested Future Research and Unanswered Questions

 

Appendixes

 

* A. Award of the Trudeau Medal of the National Tuberculosis Association to Max B. Lurie

* B. Obituary of Max B. Lurie

* C. Publications of Max B. Lurie

* D. Publications of Arthur M. Dannenberg, Jr.

* E. Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings, 2005 (Centers for Disease Control and Prevention; Table of Contents)

* F. Collected Abstracts of Chapters in This Volume

* G. Acknowledgments

 

Glossary