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This concise overview of the fundamental concepts of cancer biology is ideal for those with little or no background in the field. A summary of global cancer patterns introduces students to the general principles of how cancers arise and the risk factors involved. By focusing on fundamental examples of the signalling pathways within cells, the functional effects of DNA damage are explained. Later chapters then build on this foundation to provide a comprehensive summary of the major signalling pathways that affect tumour development. Current therapeutic strategies are reviewed, along with a discussion of methods for tumour detection and biomarker identification. Finally, the impact of whole genome sequencing is discussed, bringing students up to date with key recent developments in the field. From basic principles to insights into cutting-edge research, this book will enable the reader to move into the cancer field with confidence.

Table of Contents

 

Introduction

1. Lessons from epidemiology

2. Causes of cancer

3. Signalling in normal cells

4. 'Cancer genes': mutations and cancer development

5. What is a tumour?

6. Cancer signalling networks

7. The future of cancer prevention, diagnosis and treatment

8. The future of cancer in the post-genomic era

Ten major cancers at a glance

Appendix. Targets of specific anti-cancer drugs

Glossary

Further reading

Index.