The World Health Organization declared tuberculosis a global health emergency, and despite efforts toward eradication, the situation has intensified. Social and operational factors, including the growing AIDS epidemic and increasing drug resistance, have dramatically compounded the tuberculosis crisis. Tuberculosis and the Tubercle Bacillus, an extension of the 1994 publication Tuberculosis, is a state-of-the-art review of the corpus of knowledge available to researchers in the field.
Divided into three comprehensive sections, this new volume begins with an examination of the current issues related to tuberculosis, including clinical and epidemiological features of the disease-causing strains. Topics explored in the second section include genetics, genomics, cell structure, and metabolism of Mycobacterium tuberculosis. Tuberculosis and the Tubercle Bacillus concludes with a detailed discussion of the host-bacillus relationship and presents information on animal models and their roles in prevention of tuberculosis.
Table of Contents
Introduction
I. Historical Perspectives
* 1. Global Burden of Tuberculosis: Past, Present, and Future, Liz Corbett and Mario Raviglione
II. Clinical and Epidemiological Perspectives
* 2. Overview of Clinical Tuberculosis, Philip C. Hopewell and Robert M. Jasmer
* 3. Molecular Epidemiology of Mycobacterium tuberculosis, M. Donald Cave, Megan Murray, and Edward Nardell
III. Diagnostics
* 4. Clinical Mycobacteriology (Tuberculosis) Laboratory: Services and Methods, Leonid Heifets and Edward Desmond
* 5. Immune-Based Methods, Suman Laal and Yasir A. W. Skeiky
* 6. Molecular Diagnosis of Mycobacterial Infections, Betty A. Forbes, Gaby Pfyffer, and Kathleen D. Eisenach
IV. Current Therapies and Drug Resistance
* 7. Global Impact of Multidrug Resistance, Marcos A. Espinal and Max Salfinger
* 8. Mechanisms of Drug Resistance in Mycobacterium tuberculosis, Ying Zhang, Catherine Vilcheze, and William R. Jacobs, Jr.
The Organism Mycobacterium tuberculosis
V. Genomics
* 9. Introduction to Functional Genomics of the Mycobacterium tuberculosis Complex, Priscille Brodin, Caroline Demangel, and Stewart T. Cole
* 10. Comparative Genomics and Evolution of Mycobacterium bovis BCG, Roland Brosch and Marcel A. Behr
* 11. TB or Not TB: a Structural Genomics Mission? Celia W. Goulding, Debnath Pal, and David Eisenberg
VI. Genetics
* 12. Gene Replacement Systems, Neil G. Stoker, P. Sander, and J. M. Reyrat
* 13. Repetitive DNA in the Mycobacterium tuberculosis Complex, Stephen V. Gordon and Philip Supply
* 14. Mycobacteriophages and Tuberculosis, Graham F. Hatfull
* 15. Control of Mycobacterial Transcription, Issar Smith, William R. Bishai, and Valakunja Nagaraja
VII. Cell Structure
* 16. The Proteome of Mycobacterium tuberculosis, John T. Belisle, Miriam Braunstein, Ida Rosenkrands, and Peter Andersen
* 17. The Cell Envelope of Mycobacterium tuberculosis with Special Reference to the Capsule and Outer Permeability Barrier, Philip Draper and Mamadou Daffe
* 18. Structure, Biosynthesis, and Genetics of the Myolic Acid-Arabinogalactan-Peptidoglycan Complex, Sebabrata Mahapatra, Joyoti Basu, Patrick J. Brennan, and Dean C. Crick
* 19. A Waxy Tale, by Mycobacterium tuberculosis, Laurent Kremer and Gurdyal S. Besra
VIII. Metabolism
* 20. General Metabolism and Biochemical Pathways of Tubercle Bacilli, Paul R. Wheeler and John S. Blanchard
* 21. Iron Metabolism in the Tubercle Bacillus and Other Mycobacteria, Luis E. N. Quadri and Colin Ratledge
* 22. Two-Component Systems, Protein Kinases, and Signal Transduction in Mycobacterium tuberculosis, Yossef Av-Gay and Vojo Deretic
* 23. Nucleic Acid Metabolism, Valerie Mizrahi, Michael Buckstein, and Harvey Rubin
* 24. Transport Processes, Jean Content, Martine Braibant, Nancy D. Connell, and Jose A. Ainsa
Host-Pathogen Interactions
IX. Phagocytic Uptake and Intracellular Survival
* 25. Receptor-Mediated Recognition of Mycobacterium tuberculosis by Host Cells, Matthew J. Fenton, Lee W. Riley, and Larry S. Schlesinger
* 26. Mycobacterium tuberculosis: the Indigestible Microbe, David G. Russell
* 27. Intracellular Models of Mycobacterium tuberculosis Infection, John Chan, Richard Silver, Beate Kampmann, and Robert S. Wallis
* 28. Dendritic Cells in Host Immunity to Mycobacterium tuberculosis, Marc Mendelson, Willem Hanekom, and Gilla Kaplan
X. Host Immune Responses and Antigenic Variation
* 29. CD8 T Cells in Tuberculosis, Stefan H. E. Kaufmann and JoAnne L. Flynn
* 30. CD1 and Tuberculosis, Christopher C. Dascher and Michael B. Brenner
* 31. Th1 and Th2 Cytokines in the Human Immune Response to Tuberculosis, Peter F. Barnes and Ramakrishna Vankayalapati
* 32. Role of Antibody-Mediated Immunity in Host Defense against Mycobacterium tuberculosis, Aharona Glatman-Freedman and Arturo Casadevall
* 33. The PE and PPE Multigene Families of Mycobacteria, Michael J. Brennan, Nico C. Gey van Pittius, and Clara Espitia
XI. Animal Models
* 34. Mycobacterium marinarum and Fish and Frog Models of Infection, Michele Trucksis, Christopher L. Pritchett, and Renate Reimschuessel
* 35. Experimental Infection Models of Tuberculosis in Domestic and Wild Animals, Bryce M. Buddle, John M. Pollock, and R. Glyn Hewinson
* 36. Animal Models of Tuberculosis, JoAnne L. Flynn, Andrea M. Cooper, and William Bishai
* 37. Tuberculosis Vaccine Preclinical Screening and Development, Ian M. Orme and Angelo A. Izzo