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Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research.

 

This book provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:

 

Extensive revisions and a slight reorder of chapters for a more effective organization

A brand new chapter on next-generation sequencing

An expanded companion website, also updated as and when new information becomes available

Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command-line tools such as software for next-generation sequence analysis, the R programming language, and NCBI search utilities

The book is complemented by lavish illustrations and more than 500 figures and tables - many newly-created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software. Readers may visit a related Web page for supplemental information such as PowerPoints and audiovisual files of lectures, and videocasts of how to perform many basic operations: www.wiley.com/go/pevsnerbioinformatics.

 

Bioinformatics and Functional Genomics, Third Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

Table of Contents

 

Part I Analyzing DNA RNA and Protein Sequences

 

1 Introduction 3

 

2 Access to Sequence Data and Related Information 19

 

3 Pairwise Sequence Alignment 69

 

4 Basic Local Alignment Search Tool (BLAST) 121

 

5 Advanced Database Searching 167

 

6 Multiple Sequence Alignment 205

 

7 Molecular Phylogeny and Evolution 245

 

Part II Genomewide Analysis of DNA RNA and Protein

 

8 DNA: The Eukaryotic Chromosome 307

 

9 Analysis of Next-Generation Sequence Data 377

 

10 Bioinformatic Approaches to Ribonucleic Acid (RNA) 433

 

11 Gene Expression: Microarray and RNA-seq Data Analysis 479

 

12 Protein Analysis and Proteomics 539

 

13 Protein Structure 589

 

14 Functional Genomics 635

 

Part III Genome Analysis

 

15 Genomes Across the Tree of Life 699

 

16 Completed Genomes: Viruses 755

 

17 Completed Genomes: Bacteria and Archaea 797

 

18 Eukaryotic Genomes: Fungi 847

 

19 Eukaryotic Genomes: From Parasites to Primates 887

 

20 Human Genome 957

 

21 Human Disease 1011

 

GLOSSARY 1075

 

Self-Test Quiz: Solutions 1103

 

Author Index 1105

 

Subject Index 1109