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Written in an accessible style, Medicinal Chemistry: An Introduction, Second Edition carefully explains fundamental principles of the subject while assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. The book opens with a broad overview of the subject with subsequent chapters examining topics in greater depth. The approach to medicinal chemistry is kept as simple as possible. Each chapter includes a summary of its contents and self-assessment question as well as numerous examples and applications. Building on the success of the first edition, this edition has been completely revised and updated.

 

Aus dem Inhalt

Preface

 

Acknowledgements.

 

Abbreviations.

 

Chapter 1. An Introduction to Drugs, their Action and Discovery.

 

Chapter 2. Drug Structure and Solubility.

 

Chapter 3. Structure-activity and quantitative structures relationships.

 

Chapter 4. Computer aided drug design.

 

Chapter 5. Combinatorial Chemistry.

 

Chapter 6. Drugs from natural sources.

 

Chapter 7. Biological Membranes.

 

Chapter 8. Receptors and Messengers.

 

Chapter 9. Enzymes.

 

Chapter 10. Nucleic Acids.

 

Chapter 11. Pharmacokinetics.

 

Chapter 12. Drug metabolism.

 

Chapter 13. Complexes and chelating agents.

 

Chapter 14. Nitric oxide.

 

Chapter 15. An Introduction to drug and analogue synthesis.

 

Chapter 16. Drug Development and Production.

 

Selective further reading.

 

Answers to Questions.

 

Index.