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This volume constitutes a comprehensive review of the different aspects of tumor virology 100 years after the discovery of the Rous-sarcoma virus. Its aim is to bring a greater focus on the contributions of viral agents to the development of cancer, and to create an up to date compendium of the general molecular biology of these viruses, their gene products, and targeted functions. The content of the book comprises general chapters which tie into the many aspects of cancer-related viruses and how they contribute to cell proliferation, the genes that are responsible for driving these cancers, and their mechanisms of transmission. The book also reviews the current knowledge on the molecular biology of large DNA viruses and describes the many different pathways through which they contribute to cell proliferation. Papilloma viruses and Adenoviruses, well known to be associated with invasive carcinomas, and hepatitis viruses, HTLV and retroviruses are also discussed. This volume is dedicated to Baruch Blumberg, an outstanding scientist and recipient of the Nobel Prize for the discovery of the hepatitis B virus, who was also the author of one of the chapters.

TABLE OF CONTENTS

1. Historical Perspectives of Viruses and Cancer - Baruch Blumberg 2. Peyton Rous: A centennial tribute to the founding father of cancer virology. 3. Virus Mediated Cell Proliferation - Jae Jung 4. Viral Encoded Genes and Cancer - Blossom Damania 5. Oncogenic Viruses and Cancer Transmission- Robin Weiss 6. Overview of DNA Viruses and Cancer – James Alwine 7. Herpesviruses and Cancer – Bala Chandran 8. Lymphocryptoviruses- EBV and its role in human cancer – Erle S. Robertson 9. LCV and RRV in nonhuman primates – Scott Wong 10. Rhadinoviruses – KSHV and associated malignancies – Thomas Schultz 11. RFHV and contribution to disease –Tim Rose 12. Murine herpesvirus 68 in Tumorigenesis – Sam Speck 13. Marek’s Disease Virus and T cell Lymphomas – Mark Parcells and Robin Morgan 14. Polyoma Viruses and Cancer –Ole Gjoerup 15. SV40 as a Model System for Cancer – Janet Butel 16. BK virus and Transformation – Hans Hirsch 17. JC virus and Transformation –Kamel Khalili 18. Merkel Cell Polyoma viruses – Jurgen Becker 19. Papilloma Viruses – HPV and BPV and Cancer – Jianxin You and Suzanne Wells 20. Adenoviruses and Cell proliferation – Robert Ricciardi 21. Overview of Hepatitis Viruses and Cancer – Tim Block 22. Hepadna Viruses - HBV and Hepatocellular Carcinomas – Bill Mason 23. Hepatitis C Virus and Hepatocellular Carcinomas – Brett Lindenbach 24. Human and Animal Retroviruses: HIV-1 a Risk Factor for Malignancy – Kathleen Boris-Lawrie 25. HTLV-1 and Cell Proliferation – Chou-Zen Giam 26. HTLV-2 and Cell Proliferation – Patrick Green 27. Avian and Murine Retroviruses –Karen Beemon & Naomi Rosenberg 28. Rous Sarcoma Virus –Leslie Parent 29. Mouse Mammary Tumor Viruses – Susan Ross 30. Jaagsiekte Sheep Retrovirus and Lung Cancer – Hung Fan 31. Small RNAs and their Role in Viral Mediated Cancers - Rolf Renne & Sankar Swaminathan 32. Immunodeficiency and Opportunistic Viral infections and Cancer – Charles Wood