Branch	Locations	Status	Reservations	Due date	Barcode	Floor plan	Lending note
Branch: Hauptstelle	Locations: NA-20 25	Status: available	Reservations: 0	Due date:	Barcode: 00257281	Floor plans: Floor plan	Lending note:

New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research.

 

Intro - history and milestones

Fundamentals of DNA and RNA quadruplex structure and stability

Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance

Genomic DNA and RNA quadruplexes - involvement in gene expression and potential as therapeutic agents

Quadruplex targets and human disease - applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit

Quadruplex ligands - chemistry and design - selectivity and assays

Quadruplex ligands - basic biology and assays indirect and direct

Quadruplex ligands - pharmacology and druggability, ligands in clinical trial and pre-clinical trial development

Synthetic quadruplexes and drugs - therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding

Future directions and conclusions