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Roitt’s Essential Immunology clearly explains the key principles needed by medical and health sciences students, from the basis of immunity to clinical applications. A brand new introduction sets the scene to section 1, Fundamentals of Immunology, introducing the microbial world and the strategies the body employs to defend itself. Each chapter then guides the reader through a different part of the immune system, and explains the role of each cell or molecule individually, and then as a whole. Section 2, Applied Immunology, discusses what happens when things go wrong, and the role the immune system plays alongside the damaging effects of a disease, including cancer, immunodeficiency, allergies and transplantation and the beneficial effects of vaccines.

 

The 13th edition continues to be a user-friendly and engaging introduction to the workings of the immune system, whilst supporting those who require a slightly more detailed understanding of the key developments in immunology. The content has been fully updated throughout and includes:

 

An expansion on key clinical topics, including: innate immunity, autoimmune conditions, asthma, primary immunodeficiency, and HIV/AIDS

Beautifully presented with improved artwork and new illustrations

A range of learning features, including introduction re-cap boxes, end of chapter and section summaries to aid revision, as well as further reading suggestions, and a glossary to explain the most important immunology terms.

 

Roitt's Essential Immunology Companion sitefeatures:

An additional online only chapter on immunological methods and applications

Further interactive multiple choice and single best answer questions for each chapter

Animations and videos showing key concepts

Fully downloadable figures and illustrations, further reading and useful links

Updated extracts from the Encyclopaedia of Life Sciences

Podcasts to reinforce the key principles explained in the text

 

Table of Contents

 

About the authors vi

 

Acknowledgments viii

 

Preface ix

 

Abbreviations x

 

How to use your textbook xvi

 

About the companion website xvii

 

Part 1: Fundamentals of immunology 1

 

1 Innate immunity 3

 

2 Specific acquired immunity 52

 

3 Antibodies 69

 

4 Membrane receptors for antigen 97

 

5 Antigen-specific recognition 139

 

6 The anatomy of the immune response 167

 

7 Lymphocyte activation 187

 

8 The production of effectors 218

 

9 The regulation of the immune response 272

 

10 Development and evolution of the immune response 291

 

Part 2: Applied immunology 319

 

11 Adversarial strategies during infection 321

 

12 Vaccines 353

 

13 Immunodeficiency 378

 

14 Allergy and other hypersensitivities 405

 

15 Transplantation 435

 

16 Tumor immunology 458

 

17 Autoimmune diseases 499

 

Glossary 529

 

Index 541