Over the last decade, the field of molecular imaging of living subjects has evolved considerably and has seen spectacular advances in chemistry, engineering, and biomedical applications. In a relatively short period of time, comprehensive molecular imaging centers have been established in the US, Europe and Asia and are increasingly integrated into basic sciences and translational networks. New investigators, collaborators, and students drawn into this multidisciplinary field have often expressed the desire and need for an authoritative textbook. This textbook was designed precisely to fill this need.
Given the multidisciplinary nature of the field, the book is broken into six different sections. Part 1 (Molecular Imaging Technologies) summarizes the different macro-, meso-, and microscopic imaging technologies currently available. Part 2 (Chemistry of Melecular Imaging) is dedicated to reviewing chemical approaches to imaging probe designs for different types of imaging technologies. This section also contains chapters on the emerging field of nanomaterials, chemical biology, and probe design as well as signal amplification strategies. Part 3 (Molecular Imaging in Cell and Molecular Biology) contains chapters dedicated to protein engineering, vectors, and pathways. Part 4 (Applications of Molecular Imaging) summarizes the above advances in different clinical disease entities. Part V (Molecular Imaging in Drug Evaluation) is dedicated to imaging in drug development, and Part IV provides chapters on computation, bioinformatics, and modeling.
Table of Contents
Part I: Molecular Imaging Technologies
CHAPTER TITLE
1 General Principles of Molecular Imaging
2 Imaging of Structure and Function with PET/CT
3 PET/MRI
4 SPECT and SPECT/CT
5 Principles of Micro X-ray Computed Tomography
6 Small Animal SPECT, SPECT/CT, and SPECT/MRI
7 Instrumentation and Methods to Combine Small Animal PET
with Other Imaging <odalities
8 Functional Imaging Using Bioluminescent Imaging
9 Optical Multimodality Technologies
10 Fiber Optic Fluorescence Imaging
11 Fluorescence Tomography
12 Endomicroscopy
13 Intravital Microscopy
14 Diffuse Optical Tomography and Spectroscopy
15 Ultrasound
16 Molecular Photoacoustic Tomography
17 Optical Projection Tomography
18 Potential Roles for Retrospective Registration in Molecular Imaging
Part II: Chemistry of Molecular Imaging
19 Chemistry of Molecular Imaging: An Overview
20 Radiochemistry of PET
21 Radiochemistry of SPECT: Examples OF 99MTc and 111In Complexes
22 Nanochemistry for Molecular Imaging
23 Newer Bioconjugation Methods
24 Targeted Antibodies and Peptides
25 Hyperpolarized 13C Magnetic Resonance Imaging – Principles and Applications
26 Magnetic Resonance Imaging Agents
27 Optical Imaging Agents
28 Ultrasound Contrast Agents
29 Multimodality Agents
30 “Click Chemistry”: Applications to Molecular Imaging
31 The “One-Bead-One-Compound” Combinatorial Approach to
Identifying Molecular Imaging Probes
32 Chemical Biology Approaches to Molecular Imaging
33 Theranostics: Agents for Diagnosis and Therapy
34 Magnetic Nanoparticles
35 Fluorocarbon Agents for Quantitative Multimodal Molecular Imaging
and Targeted Therapeutics
36 Aptamers for Molecular Imaging
37 Nonclinical Product Developmental Strategies, Safety Considerations, and
Toxicity Profiles of Medical Imaging and Radiopharmaceutical Products
Part III: Molecular Imaging in Cell & Molecular Biology
38 Overview of Molecular and Cell Biology
39 Systems Biology
40 Protein Engineering for Molecular Imaging
41 Phage Display for Imaging Agent Development
42 Molecular Imaging of Gene Therapy
43 Developing Diagnostic and Therapeutic Viral Vectors
44 Cell Voyeurism Using Magnetic Resonance Imaging
45 Tumor Vasculature
46 Imaging Hypoxia
47 Molecular Imaging of Protein-Protein Interactions
48 Fluorescence Readouts of Biochemistry in Live Cells and Organisms
49 Imaging of Signaling Pathways
Part IV: Applications of Molecular Imaging
Oncology:
50 Molecular and Functional Imaging of the Tumor Microenvironment
51 Novel MR and PET Imaging in the RT Planning and Assessment of
Response of Malignant Gliomas
52 PET Diagnosis and Response Monitoring in Oncology
53 Magnetic Resonance Spectroscopy Treatment Response and Detection
54 Diffusion MRI: A Biomarker for Early Cancer Treatment Response
Assessment
Cardiovascular:
55 Myocardial Metabolism
56 Congestive Heart Failure
57 Molecular Imaging of Atherosclerosis
58 Thrombosis and Embolism
59 Molecular Imaging of Stem Cells in Myocardial Infarction
CNS:
60 Central Nervous System Molecular Imaging
61 Neuroreceptor Imaging: Applications, Advances, and Limitations
62 PET and SPET Imaging of Neurodegenerative Diseases
Autoimmune/Immunology:
63 Molecular Imaging of Autoimmune Diseases
64 Rheumatoid Arthritis
65 Autoimmune Diabetes
66 Imaging in Asthma
Part V: Molecular Imaging in Drug Evaluation
67 Molecular and Functional Imaging in Drug Development
68 PET Imaging Cancer Clinical Trials
69 MR Imaging in Clinical Trials
70 Imaging of Gene Therapy: Basis and Clinical Trials
Part VI: Other
71 Visualization
72 Quantification of Radiotracer Uptake into Tissue
73 Mining Genomic Data for Molecular Imaging Targets
74 Pharmacokinetic Modeling
75 Cost-Effectiveness Analysis/Economics of Probe Development
76 Regulatory and Reimbursement Process for Imaging Agents and Devices