This landmark volume details progress in the fast-changing world of bacterial genomics. The availability of genome sequences pervades every aspect of bacteriology. Bacteriologists now can examine the genomic sequence for every significant bacterial pathogen of humans, plants, and animals. With chapters from more than forty scientists from around the world, Bacterial Pathogenomics explains the scientific advances that have resulted from the application of bacterial genome sequencing to the study of how bacterial pathogens have evolved and how these bacteria cause disease.
The first half of the book reviews the impact of genomics on our understanding of selected groups of pathogens, including Escherichia coli, mycobacteria, Neisseria, staphylococci, spirochetes, Campylobacter, plant pathogens, and Photorhabdus. The remaining chapters cover themes that cut across taxonomic boundaries, such as genomic signatures of intracellularity, the impact of shared genomic tools and datasets, pathogenomics of bacterial biothreat agents, the impact of phages on the evolution of bacterial pathogenicity, gram-positive protein secretion, cell wall biosynthesis, and intracellular pathogens. Bacterial Pathogenomics will prove indispensable in the library of any bacteriology research group and will act as a key text for anyone studying bacterial genomics or the molecular basis of bacterial infection.
Table of Contents
1. Introduction to Bacterial Genomics, Mark J. Pallen
2. Understanding the Model and the Menace: a Postgenomic View of Escherichia coli, Roy R. Chaudhuri and Gavin H. Thomas
3. The Mycobacteria: a Postgenomic View, Marien de Jonge, Timothy P. Stinear, Stewart T. Cole, and Roland Brosch
4. Neisseria: a Postgenomic View, Lori A. S. Snyder, Philip W. Jordan, and Nigel J. Saunders
5. The Staphylococci: a Postgenomic View, Jodi A. Lindsay and Matthew T. G. Holden
6. Comparative Pathogenomics of Spirochetes, George M. Weinstock, David Smajs, Timothy Palzkill, and Steven J. Norris
7. Campylobacter Pathogenomics: Genomes and Beyond, Derrick E. Fouts, Emmanuel F. Mongodin, and Karen E. Nelson
8. Genomic Signatures of Intracellularity: Evolutionary Patterns and Paces in Bacterial Mutualists and Parasites, Jennifer J. Wernegreen
9. Modeling Microbial Virulence in a Genomic Era: Impact of Shared Genomic Tools and Datasets, Daniel G. Lee, Nicole T. Liberati, Jonathan M. Urbach, Gang Wu, and Frederick M. Ausubel
10. Pathogenomics of Bacterial Biothreat Agents, Timothy D. Read and Brendan Thomason
11. Impact of Phages on Evolution of Bacterial Pathogenicity, Harald Brüssow
12. What Has Genomics Taught Us about Gram-Positive Protein Secretion and Targeting? Olaf Schneewind and Dominique Missiakas
13. What Has Genomics Taught Us about Bacterial Cell Wall Biosynthesis? Lynn G. Dover
14. What Genomics Has Taught Us about Intracellular Pathogens: the Example of Listeria monocytogenes, Pascale Cossart and Carmen Buchrieser
15. Genomic Analysis of Plant Pathogenic Bacteria, Gail M. Preston, David S. Guttman, and Ian Toth
16. Photorhabdus: Genomics of a Pathogen and Symbiont, Richard H. French-Constant, Andrea Dowling, Michelle Hares, Guowei Yang, and Nicholas Waterfield