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Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues.

 

Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered.

 

With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come.

 

From the content:

* Discovery of Predictive Biomarkers for Anticancer Drugs

* Discovery and Development of Vemurafenib

* Targeting Basal-Cell Carcinoma

* G-Quadruplexes as Therapeutic Targets in Cancer

* From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease

* Therapeutic Potential of Kinases in Asthma

* DNA Damage Repair Pathways and Synthetic Lethality

* Medicinal Chemistry in the Context of the Human Genome

 

and many more

 

Table of Contents

Introduction

 

ONCOLOGY

Diagnostics

Crizotinib

Zelboraf

Vismodegib

G-quadruplexes as therapeutic targets in cancer

Identifying actionable targets in cancer patients

DNA damage repair pathways and synthetic lethality

 

NEUROSCIENCES

Amyloid chemical probes and theranostics: steps toward personalized medicine in neurodegenerative diseases

LRRK-2

Genes to drugs for CNS disorders

The Alzheimer's Prevention Initiation study

 

INFLAMMATION

Kinases in asthma

Epigenetics

 

FUTURE PERSPECTIVES

Future perspectives in personalized medicine

Developing targeted PET probes in the era of personalized medicine