Table of Contents
Foreward Contemporary Liver Immunology and Immunopathology: Obstacles
and Opportunuties
Ian R. Mackay, MD, FRCP, FRACP, VRCPA, FAA
Preface Clinical Use of Immunosuppressive Drugs to Control the Immune
Response
John Vierling, M.D., F.A.C.P.
Chapter 1: A Short Primer of Fundamental Immunology
Cliona O'Farrelly, Ph.D.
Derek G. Doherty, Ph.D.
Chapter 2: Role and Function of Liver Sinusoidal Endothelial Cells
Percy A. Knolle, M.D.
Chapter 3: Innate Immune Mechanisms in the Liver
Cliona O'Farrelly, Ph.D.
Derek G. Doherty, Ph.D.
Chapter 4: Antigen Processing and Presentation in the Liver
Masanori Abe, M.D., Ph.D.
Angus W. Thomson, Ph.D., DSc
Chapter 5: Adaptive Immunity in the Liver
James D. Gorham, M.D., Ph.D.
Chapter 6: Hepatic NK, NKT and T Cells
Golo Ahlenstiel, M.D.
Barbara Rehermann, M.D.
Chapter 7: Cytokines in Liver Health and Disease
Pietro Invernizzi, M.D., Ph.D.
Ilaria Bianchi, M.D.
Massimo Locati, M.D.
Raffaella Bonecchi, Ph.D.
Carlo Selmi, M.D., Ph.D.
Chapter 8: Prevalence and Significance of Autoantibodies in Acute and
Chronic Liver Diseases and Hepatocellular Carcinoma
Christian P. Strassburg, M.D.
Chapter 9: The Role of Inflammation and Immunity in the Pathogenesis of
Liver Fibrosis
Wajahat Mehal, M.D., D. Phil.
Scott L. Friedman, M.D.
Chapter 10: Clinical Use of Immunopathology Techniques in Liver Diseases
Chen Liu, M.D., Ph.D.
James M. Crawford, M.D., Ph.D.
Chapter 11: Tumor Immunology: Hepatocellular Carcinoma,
Cholangiocarcinoma and Metastatic Neoplasms
Christopher Bowlus, M.D.
Bacterial, Parasitic and Viral Infections of the Liver
Chapter 12: Innate and Adaptive Immune Responses to Bacterial and
Parasite Infections: Clinicopathological Consequences
Valentina Medici, M.D.
Lorenzo Rossaro, M.D.
Sripriya Balasubramanian, M.D.
Stuart H. Cohen, M.D.
Chapter 13: Immun Response to Hepatitis A and E Viruses: Role in
Disease Pathogenesis and Viral Elimination
Johannes Hadem, M.D.
Chapter 14: Role of the Immune Response in Hepatitis B: Determinants of
Severity,Chronicity, and Response to Antiviral Therapy
Antonio Bertoletti
Patrick Kennedy
Adam J. Gehring
Chapter 15 Immune Responses in Acute and Chronic Hepatitis C:
Implications for Prognosis and Therapy
Heiner Wedemeyer,
Chapter 16: Immunopathogenesis of Extrahepatic Manifestations in HAV,
HBV and HCV Infections: Importance of recognition and Therapy
Michael Manns,
Elmar Jaeckel,
Autoimmune Liver Diseases
Chapter 17: Immunogenetics of Autoimmune Liver Diseases: Risk Factors
for Susceptibility and Progression
Peter Tickell Donaldson, BSc, PhD
Chapter 18: Primary Biliary Cirrhosis and Autoimmune Cholangitis
Carlo Selmi, M.D., Ph.D.
Ana Lleo, M.D.
Pietro Invernizzi, M.D., Ph.D.
M. Eric Gershwin, M.D.
Chapter 19: Sclerosing Cholangitis
Sue Cullins, BSc, MB, BS, MRCP MD
Roger Chapman, BSc, MB, BS, FRCP, MD, MA
Chapter 20: Autoimmune Hepatitis
Diego Vergani, M.D., Ph.D.
Giorgina Mieli-Vergani, M.D., Ph.D.
Chapter 21: Unique Aspects of Autoimmune Hepatitis in Children
Giorgina Mieli-Vergani, M.D., Ph.D.
Diego Vergani, M.D., Ph.D.
Chapter 22: Overlap Syndromes of Autoimmune Hepatitis with Primary
Biliary Cirrhosis and Primary Sclerosing Cholangitis
Ulrich Beuers, M.D.
Christian Rust, M.D.
Chapter 23: Animal Models of Autoimmune Liver Diseases
Markus Biburger, PhD
Gisa Tiegs, PhD
Alcoholic and nonalcoholic Fatty Liver Diseases
Chapter 24: The Immune Response in the Pathogenesis of Alcoholic Liver
Disease
Lynell W. Klassen, M.D.
Geoffrey Thiele, Ph.D.
Chapter 25: Immunomodulatory Therapy for Severe Alcoholic Hepatitis:
Rationale and Efficacy
Arthur McCullough,
Chapter 26: Role of Immune Response in Nonalcoholic Fatty Liver
Diseases: Evidence in Human and Animal Studies
Liu Yang, M.D.
Anna Mae Diehl, M.D.
Acute Liver Failure
Chapter 27: Mechanisms of Acute Liver Failure
Christian Trautwein,
Alexander Koch, M.D.
Hepatotoxicity of Medications
Chapter 28: Immune Mechanisms in Drug-Induced Hepatotoxicity:
Therapeutic Implications
Zhang-Xu Liu, M.D., Ph.D.
Neil Kaplowitz, M.D.
Chapter 29: Acute and Chronic Liver Diseases Induced by Drugs or
Xenobiotics
Frank N.A.M. van Pelt, MSc, PhD
Michelle A. Carey, PhD
John B. Carey, PhD
Transplantation
Chapter 30: Clinical Use of Immunosuppressive Drugs to Control the
Immune Response
John M. Vierling, M.D., F.A.C.P.
Chapter 31: Hepatic Complications of Hematopoietic Cell Transplantation
Howard M. Shulman, M.D.
George B. McDonald, M.D.
Chapter 32: Acute and Chronic Rejection of the Liver Allograft
James Neuberger, DM, FRCP
Chapter 33: Immunologic Tolerance in Allo- and Xenografts
Aftab A. Ansari, Ph.D.
Kovit Pattanapanyasat, Ph.D.
Chapter 34: Autoimmune Diseases in Transplanted Livers
Hiromi Ishibashi, M.D.
Shinji Shimoda, M.D.
Minoru Nakamura, M.D.
M. Eric Gershwin, M.D.
Chapter 35: Immunopathogenesis and Outcomes of Recurrent Hepatitis C
James R. Burton, Jr., M.D.
Lucy Golden-Mason, Ph.D.
Hugo R. Rosen, M.D.