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Branch: Hauptstelle	Locations: ZB-90 235	Status: available	Reservations: 0	Due date:	Barcode: 00191787	Floor plans: Floor plan	Lending note:

Microarray technologies have risen to a robust and widely accepted tool in inflammation research. The first microarray publications in 1996, as well as later ground-breaking publications, were dedicated to topics in inflammation research. Since then, many opportunities but also hurdles specifically linked to the application of microarrays to inflammation topics have been envisaged and partly solved.

 

This book summarizes the most advanced technical aspects covering all steps for a thorough application of microarrays to inflammation topics – from sample generation to data analysis. In addition selected examples of successful applications of microarrays in major fields of inflammation research are presented.

 

The book is of interest to academic and industrial researchers but also clinicians who are working on inflammation related topics and would like to extend their knowledge about microarrays and the application thereof. After reading the book a researcher or clinician should be in the position to plan, perform and analyze or to critically review microarray experiments related to inflammation research.

Table of contents

 

Microarray and inflammation: an introduction.- Whole blood.- Separation of whole blood cells and its impact on gene expression.- Skin and skin models.- Adipose tissue.- Samples isolated by flow cytometry.- Magnetic cell sorting.- T7 based amplification protocols.- Amplification of cDNA from single or rare cells by global PCR (exponential amplification).- Gene expression patterns in asthma.- Gene expression profiling in neurological and neuroinflammatory disorders.- Aspects of gene expression in B-cell lymphomas.- The genes behind rheumatology.- miRNA patterns in hematopoietic malignancies.- Keep it simple: microarray cross-platform comparison without statistics.- Microarrays in drug development: regulatory perspective.- Complementary microarray technologies.