Branch	Locations	Status	Reservations	Due date	Barcode	Floor plan	Lending note
Branch: Hauptstelle	Locations: ME-20 94	Status: available	Reservations: 0	Due date:	Barcode: 00269395	Floor plans: Floor plan	Lending note:

This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

 

Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry

Helps chemists generate and screen novel chemical libraries of large size and quality

Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry

Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery

Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods

 

Table of Contents

 

Preface vii

 

Acknowledgments ix

 

Introductory Comments xi

 

Contributors xxiii

 

1 Just enough knowledge… 1

Agnieszka Kowalczyk

 

2 A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry 19

Robert A. Goodnow, Jr.

 

3 A brief history of DNA-encoded chemistry 45

Anthony D. Keefe

 

4 DN A-Compa tible Chemistry 67

Kin-Chun Luk and Alexander Lee Satz

 

5 Foundations of a DNA-encoded library (DEL) 99

Alexander Lee Satz

 

6 EXERCISES IN THE SYNTHESIS OF DNA-ENCODED LIBRARIES 123

Steffen P. Creaser and Raksha A. Acharya

 

7 the dna tag: A Chemical gene designed for DNA-encoded libraries 153

Andrew W. Fraley

 

8 Analytical challenges for DNA-encoded library systems 171

George L. Perkins and G. John Langley

 

9 Informatics: Functionality and architecture for DNA-encoded library production and screening 201

John A. Feinberg and Zhengwei Peng

 

10 Theoretical considerations of the application of DNA-encoded libraries to drug discovery 213

Charles Wartchow

 

11 Begin with the End in Mind: The hit-to-lead process 231

John Proudfoot

 

12 Enumeration and Visualization of Large Combinatorial Chemical Libraries 247

Sung-Sau So

 

13 Screening Large Compound Collections 281

Stephen P. Hale

 

14 Reported applications of DNA-encoded library chemistry 319

Johannes Ottl

 

15 Dual-Pharmacophore DNA-Encoded Chemical Libraries 349

Jörg Scheuermann and Dario Neri

 

16 Hit Identification and Hit Follow-up 357

Yixin Zhang

 

17 Using DNA to Program Chemical Synthesis, Discover New Reactions, and Detect Ligand Binding 377

Lynn M. McGregor and David R. Liu

 

18 the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches 417

Robert A. Goodnow, Jr.

 

19 Keeping the promise? An outlook on DNA chemical library technology 427

Samu Melkko and Johannes Ottl

 

Index 435