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Viral infections of the central nervous system or neurotropic viruses are often lethal. These diseases range from polio and measles, to rabies, Varicella-zoster, Herpes, West Nile, Japanese encephalitis, and AIDS. Such infections have profound public health consequences, and the understanding of these diseases involves understanding the interaction between the nervous system and the immune system. This book shows each individual virus, discussing the diseases they cause and the mechanisms by which they cause and spread those diseases. Detection, treatment and prevention are also discussed. Included is coverage of novel and beneficial uses of neurotropic viruses for gene therapy and tumor lysis. Neurotropic Viral Infection has been written in a style suitable for a wide professional audience, and will appeal to anyone from graduate students and postdocs to clinicians and public health professionals.

 

• Introduction and explanation of each important virus, and a description of the diseases they cause • Discussion of novel applications of neurotropic viruses e.g. treatment of inborn errors of metabolism or elimination of brain tumors • Discusses current and possible future techniques to diagnose both well understood and emerging infections

Contents

 

Preface. Howard Lipton; Forward and acknowledgments Carol Shoshkes Reiss; Part I. RNA Viruses: Introduction Carol Shoshkes Reiss; 1. Neurotropic picornaviruses Vincent Racaniello; 2. Subacute sclerosing panencephalitis James Bale and Robert S. Fujinami; 3. Rabies Monique Lafon; 4. Neurotropic coronavirus infections Stanley Perlman and Noah Butler; 5. Arenavirus infection in the nervous system: uncovering principles of virus-host interaction and viral pathogenesis Stefan Kunz and Juan-Carlos de la Torre; 6. Neurotropic alphaviruses Diane E. Griffin; 7. Flaviviruses Barbara W. Johnson; Part II. Retroviruses, DNA Viruses and Prions: Introduction Carol Shoshkes Reiss; 8. HTLV-1 and disease in the central nervous system Angelina J. Mosley and Charles R. M. Bangham; 9. HIV infection of the central nervous system Iain C. Anthony P Simmonds and J. E. Bell; 10. JC virus molecular biology and the human demyelinating disease, progressive multifocal leukoencephalopathy Kamel Khalili, Mahmut Safak, Luis Del Valle and Martyn K. White; 11. Herpes simplex viruses David C. Bloom and Nicole V. Giordani; 12. Pathogenesis of varicella-zoster virus neurotropism and infection Leigh Zerboni and Ann M. Arvin; 13. Transmissible spongiform encephalopathies Surachai Supattapone and Judy R. Rees; Part III. Immunity, Diagnosis, Vectors and Beneficial Uses of Neurotropic Viruses: Introduction Carol Shoshkes Reiss; 14. Innate immunity in the CNS Carol Shoshkes Reiss; 15. The role of toll like receptors in neurotropic viral infections Robert W. Finberg, Shenghua Zhou and Evelyn A. Kurt-Jones; 16. Neuro-endocrine-immune networks in viral infections C. Jane Welsh, Andrew J. Steelman, Amy N. Sieve, Wentao Mi, Robin R. Johnson, Colin R. Young, Thomas W. Prentice and Mary W. Meagher; 17. Epidemiology of viral encephalitis Nino Khetsuriani and Larry J. Anderson; 18. Pathogen surveillance and discovery W. Ian Lipkin and Thomas Briese; 19. Clinical management of viral encephalitis Kenneth L. Tyler and Don Gilden; 20. Influences of arthropod vectors on encephalitic arboviruses Stephen T. Higgs; 21. The role of bats as reservoir hosts of emerging neurological viruses John S. Mackenzie, James E. Childs, Hume E. Field, Lin-Fa Wang and Andrew C. Breed; 22. Viral oncolysis of glioblastoma William T. Curry, Jr. and Robert L. Martuza; 23. Viral gene therapy for central nervous system disorders Pedro R. Lowenstein, Kurt M. Kroeger and Maria G. Castro.