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Species of the Bordetella genus are the causative agents of pertussis or whooping cough. It is almost twenty years since the last book totally devoted to Bordetella was published. Since then, research on Bordetella has made extensive use of molecular biology approaches, including genomics and post-genomics, and an enormous amount of new information has become available. World-wide, pertussis still kills between 200,000 and 400,000 children each year, and the disease still ranks 6th among the causes of death due to infection. A more profound molecular understanding of Bordetella may ultimately help to better control the disease.

 

This book gathers the contributions of the world's most knowledgeable investigators on the various aspects of Bordetella molecular biology. The chapters cover comparative genomics, molecular epidemiology, genetic regulation, molecular characterisation of important virulence factors, including adhesins, toxins, secretion systems, Bordetella phages, molecular aspects of bacterial physiology, and applications in biotechnology and vaccine research.

 

The book is written by 28 scientists from ten different countries, all actively working in the field. The chapters cover a broad spectrum of Bordetella-related issues with a focus on molecular aspects.

 

An essential book for anyone interested in Bordetella, pertussis, whooping cough, bacterial pathogenesis and vaccine development.

 

Chapter List:

 

Chapter 1

Speciation in the Genus Bordetella as Deduced from Comparative Genome Analyses

Andrew Preston, Louise Temple, Mohammed Sebaihia, Julian Parkhill and Duncan J. Maskell

 

Chapter 2

Phylogeny, Evolution and Epidemiology of Bordetellae

Frits R. Mooi, Qiushui He and Nicole Guiso

 

Chapter 3

The Bvg Regulon

Scott Stibitz

 

Chapter 4

The Bordetella Adhesins

Françoise Jacob-Dubuisson and Camille Locht

 

Chapter 5

Bordetella Toxins

Erik L. Hewlett and Gina M. Donato

 

Chapter 6

Type III Secretion in Bordetella Subspecies

Natalia A. Kozak, Ekaterina M. Panina and Jeff F. Miller

 

Chapter 7

The Ptl Type IV Secretion System

Amy A. Rambow-Larsen and Alison A. Weiss

 

Chapter 8

Primary Metabolism and Physiology of Bordetella Species

Sandra K. Armstrong and Roy Gross

 

Chapter 9

Bordetella Bacteriophage and Diversity-Generating Retroelements

Asher Hodes, Roman Barbalat, Louise Temple and Jeff F. Miller

 

Chapter 10

Biotechnological Applications of the Bordetella pertussis Adenylate cyclase toxin

Marcela Simsova, Gouzel Karimova, Peter Sebo and Daniel Ladant

 

Chapter 11

Pertussis Vaccines

Jann Storsaeter, Joanne Wolter and Camille Locht