Case Studies in Immunology, Sixth Edition, presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. The case histories illustrate essential points about the mechanisms of immunity and describe immunological problems seen in the clinic. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. Case Studies in Immunology highlights major common disorders of immunity, including hypersensitivity types I-IV, immune deficiencies, and autoimmune disorders. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the specific disorders. An end-of-case summary, questions, and discussion points conclude each case.
Case Studies in Immunology can be used as a stand-alone book, or as a clinical companion alongside Janeway’s Immunobiology, Eighth Edition. A marginal icon in Janeway’s Immunobiology provides the reader with a link to the relevant Case Study, where the science is applied in a clinical setting.
The book includes a total of 53 cases. The Sixth Edition is extensively revised and updated and includes ten new cases:
DiGeorge Syndrome
Hemophagocytic Lymphohistiocytosis
Chediak-Higashi Syndrome
Hyper IgE Syndrome
Ataxia Telangiectasia
Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome
Severe Congenital Neutropenia
Recurrent Herpes Simplex Encephalitis
Systemic Onset Juvenile Idiopathic Arthritis
Crohn’s Disease
Case 1 X-linked Agammaglobulinemia
Case 2 CD40 Ligand Deficiency
Case 3 Activation-induced Cytidine Deaminase Deficiency
Case 4 Common Variable Immunodeficiency
Case 5 X-linked Severe Combined Immunodeficiency
Case 6 Adenosine Deaminase Deficiency
Case 7 Omenn Syndrome
Case 8 MHC Class II Deficiency
Case 9 DiGeorge Syndrome
Case 10 Acquired Immune Deficiency Syndrome (AIDS)
Case 11 Graft-Versus-Host Disease
Case 12 MHC Class I Deficiency
Case 13 X-linked Lymphoproliferative Syndrome
Case 14 Hemophagocytic Lymphohistiocytosis
Case 15 Chediak-Higashi Syndrome
Case 16 Wiskott-Aldrich Syndrome
Case 17 Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy
Case 18 Immune Dysregulation, Polyendocrinopathy, Enteropathy X-linked Disease
Case 19 Autoimmune Lymphoproliferative Syndrome (ALPS)
Case 20 Hyper IgE Syndrome
Case 21 Ataxia Telangiectasia
Case 22 Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome
Case 23 X-linked Hypohidrotic Ectodermal Dysplasia and Immunodeficiency
Case 24 Interferon- Receptor Deficiency
Case 25 Severe Congenital Neutropenia
Case 26 Chronic Granulomatous Disease
Case 27 Leukocyte Adhesion Deficiency
Case 28 Recurrent Herpes Simplex Encephalitis
Case 29 Interleukin 1 Receptor-associated Kinase 4 Deficiency
Case 30 Congenital Asplenia
Case 31 Hereditary Angioedema
Case 32 Factor I Deficiency
Case 33 Deficiency of the C8 Complement Component
Case 34 Hereditary Periodic Fever Syndromes
Case 35 Systemic Onset Juvenile Idiopathic Arthritis
Case 36 Rheumatoid Arthritis
Case 37 Systemic Lupus Erythematosus
Case 38 Mixed Essential Cryoglobulinemia
Case 39 Crohn’s Disease
Case 40 Multiple Sclerosis
Case 41 Autoimmune Hemolytic Anemia
Case 42 Myasthenia Gravis
Case 43 Pemphigus Vulgaris
Case 44 Celiac Disease
Case 45 Acute Infectious Mononucleosis
Case 46 Hemolytic Disease of the Newborn
Case 47 Toxic Shock Syndrome
Case 48 Lepromatous Leprosy
Case 49 Acute Systemic Anaphylaxis
Case 50 Allergic Asthma
Case 51 Atopic Dermatitis
Case 52 Drug-induced Serum Sickness
Case 53 Contact Sensitivity to Poison Ivy
Answers
Figure Acknowledgments
Index