The first book dedicated to the bioinformatics of carbohydrates and glycoproteins, Bioinformatics for Glycobiology and Glycomics: An Introduction provides a state-of-the-art overview and demonstrates the value of bioinformatics for glycobiology, not simply as a review of databases and tools but rather as an introduction to a new branch of glycobiology. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis, and experimental costs. The author illustrates ways to use bioinformatics to enhance glycomics data mining and improve glycomics analysis.
Aus dem Inhalt
Preface
1. Glycobiology, Glycomics and (Bio)Informatics - Claus-Wilhelm von der Lieth
2. Introduction to Carbohydrate Structure and Diversity - Stephan Herget, René Ranzinger, Robin Thomson, Martin Frank, Claus-W. von der Lieth
3. Digital Representations of oligo-and polysaccharides - Stephan Herget, Claus-W. von der Lieth
4. Evolutionary Considerations in Studying the Sialome: Sialic Acids and the Host-Pathogen Interface - Amanda L. Lewis and Ajit Varki
5. Carbohydrate-active Enzymes Database: Principles and Classification of Glycosyltransferases - Pedro M. Coutinho, Corinne Rancurel, Mark Stam, Thomas Bernard, Francisco M. Couto, Etienne G. J. Danchin, Bernard Henrissat
6. Other Databases Providing Glycoenzyme Data - Thomas Lütteke, Claus-W. von der Lieth
7. Bioinformatics Analysis of Glycan Structures from a Genomic Perspective - Kiyoko F. Aoki-Kinoshita
8. Glycosylation of Proteins - Claus-W. von der Lieth and Thomas Lütteke
9. Prediction of Glycosylation Sites in Proteins - Karin Julenius, Morten B. Johansen, Yu Zhang, Søren Brunak, Ramneek Gupta
10. Experimental Methods for the Analysis of Glycans and their Bioinformatics Requirements - Claus-W. von der Lieth
11. Analysis of N- and O-glycans of Glycoproteins by HPLC Technology - Anthony H. Merry, Sviatlana A. Astrautsova
12. Glycomic Mass Spectrometric Analysis and Data Interpretation Tools - Niclas G. Karlsson, Nicolle H. Packer
13. Software Tools for Semi-Automatic Interpretation of Mass Spectra of Glycans - Kai Maass, Alessio Ceroni
14. Informatics Concepts to Decode Structure-Function Relationships of Glycosaminoglycans - Rahul Raman, S. Raguram, Ram Sasisekharan
15. NMR Databases and Tools for Automatic Interpretation of Spectra of Carbohydrates - Claus-W. von der Lieth
16. Automatic Spectrum Interpretation Based on Increment Rules: CASPER - Roland Stenutz
17. Interpretation of ¯13C-NMR Spectra by Artificial Neural Network Techniques (NeuroCarb) - Andreas Stoeckli, Matthias Studer, Brian Cutting, Beat Ernst
18. Conformational Analysis of Carbohydrates - A Historical Overview - Martin Frank
19. Predicting Carbohydrate 3D Structures Using Theoretical Methods - Martin Frank
20. Synergy of Computational and Experimental Methods in Carbohydrate 3D Structure Determination and Validation - Thomas Lütteke, Martin Frank
21. Structural Features of Lectins and Their Binding Sites - Remy Loris
22. Statistical Analysis of Protein Carbohydrate Complexes Contained in the PDB - Thomas Lütteke, Claus-W. von der Lieth
Appendix A. List of Available Websites
Appendix B. Glossary