Kurzbeschreibung
This groundbreaking text systematically presents the principles, methodology, applications, and challenges of mouse models of human cancer. Divided into five sections, the primary focus of this book is the generation of genetically accurate models of specific human cancer types. The introduction covers nonspecific modeling systems, with chapters on animal handling, comparison of mouse and human developmental genetics and cancer, and pathology techniques. The following section covers methods for genetic manipulation of the mouse. The core section on diseases is organized by organ system, in which a brief overview of the biology of each of the main human tumor types and the current mouse modeling systems that mimic those tumors is discussed. The next section focuses on anatomic and molecular imaging techniques from CT and MRI to bioluminescence, fluorescence, and PET. The last section covers topics related to preclinical trials, from trial design to pharmacokinetics and finally regulatory issues. A final chapter provides a perspective on future directions for the field.
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Preface.
Contributors.
PART I: MOUSE HANDLING AND ENGINEERING.
1. Approaches to Handling, Breeding, Strain Preservation, Genotyping, and Drug Administration for Mouse Models of Cancer (Dawnalyn Boggess, Kathleen A. Silva, Carlisle P. Landel, Larry Mobraaten, and John P. Sundberg).
2. Pathology of Mouse Models of Cancer (Robert D. Cardiff).
3. Intercurrent Infections in Genetically Engineered Mice (Stephen W. Barthold).
4. Germline Modification Strategies (Silvia Grisendi and Pier Paolo Pandolfi).
5. Somatic Cell Gene Transfer (Lene Uhrbom and Eric C. Holland).
PART II: ORGAN SITE-SPECIFIC MOUSE MODELS OF HUMAN CANCER.
6. Lung Cancer (Jonathan M. Kurie, Parviz Minoo, Stephen S. Hecht, Alexander Nikitin, and Franco J. DeMayo).
7. Mammary Gland Cancer (Dalit Barkan, Cristina Montagna, Thomas Ried, and Jeffrey E. Green).
8. Prostate Cancer (Katharine Ellwood-Yen and Charles Sawyers).
9. Skin Cancer (Marcus Bosenberg).
10. Ovarian Cancer (Sandra Orsulic).
11. Peripheral Nervous System Tumors (David H. Gutmann, Arie Perry, Reshma Rangwala, and Larry S. Sherman).
12. Central Nervous System Tumors (Andrew B. Lassman and Eric C. Holland).
13. Myeloid Malignancies (Scott C. Kogan).
14. Lymphoid Malignancies (Michael Teitell and Pier Paolo Pandolfi).
PART III: GENERAL ISSUES IN CANCER BIOLOGY.
15. Genetic Modifiers (David W. Threadgill, Kent W. Hunter, Fei Zou, and Kenneth F. Manly).
16. Modeling Blood Vessel Formation in the Mouse (Robert Benezra, Shahin Rafii, and David Lyden).
17. Metastasis (Dawn S. Chandler and Guillermina Lozano).
18. Immunologic Study of Tumors in Mouse Models (Taha Merghoub and Alan N. Houghton).
PART IV: IMAGING TECHNOLOGIES.
19. Micro-Computed Tomography of Mouse Cancer Models (Jamey P. Weichert).
20 .Magnetic Resonance Imaging in Mouse Cancer Models (Manickam Muruganandham and Jason A. Koutcher).
21. Bioluminescent Imaging of Mouse Cancer Models (Christopher H. Contag).
PART V: PRECLINICAL TRIALS.
22 .Use of Magnetic Resonance Imaging for Evaluation of Treatment Response (Brian D. Ross, Thomas L. Chenevert, Bradford A. Moffat, Alnawaz Rehemtulla, Daniel E. Hall, Patrick McConville, and Jonathan Moody).
23. Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling (Raymond S. H. Yang, James E. Dennison, Melvin E. Andersen, Ying C. Ou, Kai H. Liao, and Brad Reisfeld).
24. Trial Design and Biostatistics (Michael F. W. Festing).
25. Cancer Drug Development in the Modern Era (William R. Sellers and Alex Matter).
26. Preclinical Trials in Mouse Cancer Models (Brian Weiss and Kevin Shannon).
Index.