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The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book aims to give principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens.

 

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Preface.

 

Health and Safety.

 

Nomenclature, Symbols and Conventions.

 

Amount Concentration and Mass Concentration.

 

Acknowledgements.

 

List of Abbreviations.

 

1. Analytical Toxicology: Overview.

 

2. Sample Collection, Transport, and Storage.

 

3. Sample Preparation.

 

4. Colour Tests, and Spectrophotometric and Luminescence techniques.

 

5. Introduction to Chromatography and Capillary Electrophoresis.

 

6. Thin-Layer Chromatography.

 

7. Gas Chromatography.

 

8. High-Performance Liquid Chromatography.

 

9. Capillary Electrophoretic Techniques.

 

10. Mass Spectrometry.

 

11. Trace Elements and Toxic Metals.

 

12. Immunoassays and Enzyme-Based Assays.

 

13. Toxicology Testing at the Point of care.

 

14. Basic Laboratory Operations.

 

15. Absorption, Distribution, Metabolism and Excretion of Xenobiotic Compounds.

 

16. Pharmacokinetics.

 

17. Clinical Interpretation of Analytical Results.

 

Index.