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The Comprehensive Sourcebook of Bacterial Protein Toxins 4th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.

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Evolutionary Aspects of Toxin-Producing Bacteria

Mobile Genetic Elements and Pathogenicity Islands Encoding Bacterial Toxins

Toxin Secretion Systems

Diphtheria Toxin

Pseudomonas aeruginosa Toxins

Bordetella Proteins Toxins

Cholera Toxin, Escherichia coli Thermolabile Enterotoxin and Other Vibrio cholerae Enterotoxins

Vibrio parahaemolyticus Virulence Determinants

Salmonella Toxin and Virulence Factors

The Shiga Toxins

Clostridial Neurotoxins: Cellular and Molecular Actions

Clostridial Neurotoxins: Uptake and Transport

Bacillus anthracis Toxins

ADP-Ribosylating Toxins Modifying the Actin Cytoskeleton

Large Clostridial Cytotoxins Modifying Small GTpases: Structure Aspects

Large Clostridial Cytotoxins Modifying Small GTpases: Cellular Aspects

Pasteurella multocida Toxin

Deamidating Toxins

Helicobaster pylori Vacuolating Toxin

Bacterial Genotoxins

Basic Mechanism of Pore-Forming Toxins

Membrane-Damaging and Cytotoxic Phospholipases

Structure and Mode of Action of RTX Toxins

Perfringolysin and Related Cholesterol-Dependent Cytolysins

Staphylococcus aureus Alpha Toxin and Leucocidins

Aerolysin

Structural Relationships Between Small ß-Pore-forming Toxins from Clostridium perfringens

Clostridium perfringens Enterotoxin

Bacillus cereus Enterotoxins

Bacillus Insecticidal Toxins

Escherichia coli Heat-Stable Enterotoxins

Superantigne Toxins

Clostridial Toxins in the Pathogenesis of Gangrene

Engineering of Botulinum Neurotoxins as Novel Therapeutic Tools

Engineering of Bacterial Toxins for Research and Medicine

Toxins as Tools in Cell Biology

Inhibitors of Toxin Endocytosis

Inhibitors of Pore-Forming Toxins

Bacterial Toxins as Biological Weapons